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《Chinese Journal of Integrated Traditional and Western Nephrology》 2006-10
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Effects of Quercetin on Renal Interstitial Fibrosis and Expression of α-SMA in UUO Rats

ZHANG Xiaoxuan,NA Yu,MIAO Lining,et alDepartment of Nephrology,the Fourth Hospital, Jilin University,Changchun (130011)  
Objective:To observe the effects of Quercetin on the pathological changes of renal interstitial fibrosis and the expression of α-SMA in kidney of UUO rats, discuss therapeutic function and mechanism of Quercetin in renal interstitial fibrosis.Methods:36 adult healthy Wistar rats randomly divided into 3 groups (n=12): sham group, UUO group and Quercetin group. Animal were euthanized at day 10 after surgery. The content of hydroxyproline in obstructed kidney tissue was measured by chemistry colorimetry method. Histological changes were observed by HE and Masson stains. The expression of α-SMA was assessed by immunohistochemistry and western blot analysis.Results:The interstitial fibrosis of obstructed kidneys was observed obviously at 10 d after UUO. The immunohistochemistry and western blot analysis indicated that obstruction significantly increased the expressions of α-SMA in renal interstitial tissue in UUO group and Quercetin group compared with sham group(P0.01).The expressions of α-SMA in renal interstitial tissue in Quercetin group significantly decreased compared with UUO group(P0.01).The content of hydroxyproline in Quercetin group was significantly lower than that in UUO group(P0.05).Conclusion:Quercetin can alleviate the pathological changes of renal interstitial fibrosis and decrease the expressions of α-SMA in UUO rats. Quercetin exert the anti-fibrosis effect in renal interstitial fibrosis, maybe through preventing renal tubular epithelial cells to transform into myofibroblast phenotype.
【CateGory Index】: R693
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 QI Li Hong 1, KANG Lu Ping 1, ZHANG Jun Ping 2 *, LIU Fu Tang 2, ZHOU Jian Ping 2, ZHOU Bin 2 (1. Department of Pharmacy, Fuzhou General Hospital, PLA Nanjing Military Area Command, Fuzhou 350001, China; 2. Department of Biochemical Pharmacy,;Inhibitive effects of genistein and quercetin on NIH3T3 fibroblast proliferation and collagen synthesis[J];Academic Journal of Second Military Medical University;2001-12
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 ZHANG Zi-qiang,ZHAO Dong-xu,YANG Xin-lin(School of Life Science and Technology,Beijing Institute ofTechnology,Beijing 100081,China);Research and Development of Hydroxyproline[J];Amino Acids & Biotic Resources;2006-01
2 CAO Chuan, DAI Xia, LI Shi-rong, LI Dan, ZHANG Yi, FENG Zhi, CHEN Yan-qing (Department of Plastic Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Effects of genistein on proliferation and invasion of human keloid fibroblasts[J];Acta Academiae Medicinae Militaris Tertiae;2008-17
3 Yan-Fang Liu1, Li Qin1, Da Zhang2, Cai-Juan Han31Department of Ophthalmology, the First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China;2Department of Surgery, Xi'an Central Hospital, Xi'an 710003, Shaanxi Province, China;3Medical Affairs, Xi'an Health Bureau, Xi'an 710002, Shaanxi Province, China;Progress of the biological activity of the quercetin[J];International Journal of Ophthalmology;2009-05
4 HUANG Liang,JI Xianfei,CAO Chunshui,et al.Department of Emergency medicine,the First Affiliated Hospital of Jiangxi Medical College,Nanchang 330006,China;Protective effects of quercetin in rats with lipopolysaccharide-induced acute lung injury[J];Journal of Emergency Medicine;2004-02
5 ZHOU Bin ZHANG Jun-pin , LIU Hong YIN Ming QIAN Ding-hua Department of Pharmacology, School of Pharmacy, Department of Stomatology, Changhai Hospital, Second Military Medical University, Shanghai 200433 , China;Effects of quercetin on hepatocyte stimulating factor production by mouse peritoneal macrophages[J];中国人民解放军军医大学学报(英文版);2003-02
6 Ji Xian-fei 1, Liu Wei 2, Huang Liang 1 (1.Department of Emergency Medicine,the First Affiliated Hospital of Jiangxi Medical College,Nanchang 330006,China; 2.Department of Pharmacy,the Infections Disease Hospital of Jining,Jining 272027,China);Effects of Quercetin on P-selectin of Rats with Acute Lung injury Induced by lipopolysaccharide[J];Practical Clinical Medicine;2004-03
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 QI Li Hong 1, KANG Lu Ping 1, ZHANG Jun Ping 2 *, LIU Fu Tang 2, ZHOU Jian Ping 2, ZHOU Bin 2 (1. Department of Pharmacy, Fuzhou General Hospital, PLA Nanjing Military Area Command, Fuzhou 350001, China; 2. Department of Biochemical Pharmacy,;Inhibitive effects of genistein and quercetin on NIH3T3 fibroblast proliferation and collagen synthesis[J];Academic Journal of Second Military Medical University;2001-12
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 Zhang Min, Zhang Junping, Wang Jiesong, Qian Dinghua (Department of Biochemical Pharmacy, College of Pharmacy, Second Military Medical University, Shanghai, 200433);Effects of fisetin on proliferation and collagen synthesis of HSCT6 cells[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1999-05
2 Yang Zhihua; Zhu Maoxiang; Gong Yifen; Ge Guixiu (Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850);Study on the application of the method of determination of hydroxyproline in rat lung[J];Bulletin of The Academy of Military Medical Sciences;1995-01
3 Feng Zhimin,Xu Heng (Department of Biochemistry,Nanjing Railway Medical College,Nanjing,210009) Ma Wangkou (Department of Chest Surgery ,The Affiliated Hospital of Nanjing Railway Medical College, Nanjing,210009);Assay of Hydroxyproline in Animal Tissues and Preliminary Application[J];JOURNAL OF NANJING RAILWAY MEDICAL COLLEGE;1999-03
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