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《Chinese Journal of Integrated Traditional and Western Nephrology》 2009-09
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The Effect of Gynostemma Pentaphylla Powder on the Renal Angiotension and Endothelin's expression in Diabetic Nephropathy Rats

HUANG Ping,JIN Lijun,QIAN KangZhejiang Chinese Medical Hospital,Hangzhou(310006)  
Objective:Observing the effect of on the renal angiotension and endothelin's expression in diabetic nephropathy,to find out the possible mechanism of the therapeutical effect of gynostemma pentaphylla powder to diabetic nephropathy.Methods:The experimental rats were divided into six groups:normal group,model group and treatment groups(high、middle、low dose groups of gynostemma pentaphylla powder and the Valsartan group).The content of the angiotensionⅡ and endothelin-1 in kidney,the expression of mRNA of angiotensinogen receptor 1 and endothelin receptor A in kidney were observed.Results:The content of the angiotensionⅡ and endothelin-1 in kidney,the expression of mRNA of the angiotensinogen receptor 1 and endothelin receptor A in kidney in treatment groups was lower than the model group,the difference were significant(P0.05 or P0.01).Conclusion:Gynostemma pentaphylla powder can be used to treat early diabetic nephropathy,and the mechanism maybe is regulating the disorder of the renin-angiotension system and the endothelin system.
【Fund】: 浙江省中医药管理局基金资助项目(No.2008CA009)
【CateGory Index】: R285.5
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