Protective effects of preconditioning and postconditioning against the intestines I/R injury
LIU Ke-xuan,HUANG Wen-qi
Intestines Ischemia-Reperfusion ( I/R ) is the common organs injury in surgical practices, previous studies demonstrates the intestines I/R produce the damages not only on the intestines, but also brings about the bacterial translocation, and result in the systemic inflammatory response syndrome, even the multiple organ dysfunction syndrome. Intestines I/R injury has been focusing by researchers at home or abroad. The authors suggest that intestines I/R injury is related to the oxidative damage, calcium overload, leukocyte adhesion, complement activation, proinflammatory mediators release, apopotosis, and NO or endothelin activation. They have performed the strategies according to these different mechanisms, such as the traditional Chinese drug (Si ni tang, Ginkgo biloba extract), anesthetics (propofol), electric stimulations on the vagus nerve, and preconditioning or postconditioning methods, these strategies present protective effects, especially the promising methods as postconditioning. The authors introduce the protective effects of preconditioning and postconditioning against the intestines I/R injury.