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《ACTA ACADEMIAE MEDICINAE JIANGXI》 1998-03
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A Study of the Quantitative Changes and Effect of Endothelin on Blood,Liver,Kidney,Stomach and Lung Tissues of Rats with Obstructive Jaundice

Liu Yingbin; Jiang Xiaogiang; Liu Fen; Luo Zhigiang(The Second Affiliated Hospital of Jiangxi Medical College,Nanchang 330006)Peng Skuyong(The Second Affiliated Hospital of Zhejian Medical University, Hangzhou 310009)He Xiaowei(Shongjiang County People's  
In order to observe the secretion of endothelin in liver,kidney,stomach,lung tissues andblood after ligation of the common bile duct and to evaluate the role of endothelin in obstructive jaundice, the concentration of endothelin in tissues of liver, kidney, stomach, lung andblood and that of cholyglycin in liver and blood were determined 5, 10, 15, 20 and 25 days respectively after ligation of common bile duct by radioimmunoassay. The histopathologicalchanges of these tissues were examined. The results showed that concentrations of endothelinand cholyglycin in blood and liver elevated progressively and correlated positively (P0.05). The concentrations of endothelin in kidney,stomach and lung tissues also elevated (P0.05). Histological examination showed that the above tissues were damaged progessivelywith prolonged ligation of the bile duct. It is suggested that endothelin may be an importantfactor leading to damage of liver in obstructive jaundice,and may have important pathophysiological significance in triggering multisystemic failure after obstructive jaundice.
【CateGory Index】: R96
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