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《Acta Academiae Medicinae Jiangxi》 2001-04
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The Study on Nitric Oxide Increase Injury of Rabbit Liver during Ischemia-Reperfusion

CHENG Shu bang, HONG JIAN qing, SHEN Mao xing (Department of General Surgery,The Second Affiliated Hospital of Jiangxi Medical College, Nanchang 330006,China)  
Aims:t o investigates the role of Nitric Oxide (NO) in hepatic Ischemia-Reperfusion injury. Methods: 50 rabbits were randomly divided into 5 groups, Blood was sampled for testing nitrate, Glutamic Pyruvic transaminase (GPT) and for Lipid Peroxide(LPO), liver tissue was sampled for pathological mophology. Results: NO production was induced by pretreatment with Escherichia Coli Lipopo Lysaccharide(LPS). The induction leads to an increase in hepatic injury during Ischemia-Reperfution and was ameliorated by the NG Monomethyl L Arginine(L NAME). LPO during Ischemia Reperfution,a measure of lipid peroxidation, was increased and was also decreased by L NAME.Conclusions:the data suggest that NO may increase rabbit liver injury during Ischemia Reperfusion by increasing lipid peroxidation.
【CateGory Index】: R657.3
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