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《Acta Academiae Medicinae Jiangxi》 2003-04
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Clinical Study of the effect of Anisodaminum on Myocardial Protection in Patients Undergoing Valve Replacement

TANG Yan hua, CHEN Peng, HU Da ren, DENG Gen ying, XU Jian jun, ZHANG Run xiang (Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Jiangxi Medical College,Nanchang 330006,China)  
Objective To observe the protective effect of anisodaminum(654 2) on myocardial ischemic and reperfusion injury in patients during cardiopulmonary bypass(CPB).Methods Thirty eight patients undergoing valve replacement were randomly divided into two groups: the test group( n =19)receiving 654 2 added to conventional cardioplegic(15 mg/500 ml) and contrast group( n =19)receiving conventional cardioplegic during operation.The blood samples were taken at seven different intervals for assessing the levels of surperoxide dismutase(SOD)?malondialdehyde (MDA) and LDH?CPK.Cardial resuscitation and use of positive inotropic drugs were observed.Results The levels of SOD decreased in both two groups with more markedly in control group during CPB. The levels of SOD recovered at one day after operation in the test group but at three days after operation in control group.The levels of MDA increased in two groups and more markedly in control group during CPB and restored at three days after operation. The ratio of active cardial resuscitation in 654 2 group was higher than that in control group.The amount of positive inotropic drugs in control group was more than that in 654 2 group.Conclusion This study suggests that 654 2 can protect the activity of SOD and decrease the production of MDA in order to reduce myocardio ischemic and reperfusion injury,although it need pass a long period of time for such injury to be covered.
【Fund】: 江西省卫生厅科学研究基金资助项目 9815 8
【CateGory Index】: R542.5
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