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《Acta Academiae Medicinae Jiangxi》 2005-03
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Chemotherapy-Induced Myelosuppression: Clinical Analysis of Risk Factors

LIU Qiu-ju, JIANG Yu-zhen, JIA Jiao-yuan(Department of Hemotology,the Second Hospital,Jilin University,Changchun 130041,China)  
Objective To analyze the risk factors of sever mylosuppression.Methods The potential risk factor related to myelosuppression was managed by univiriate analysis in 118 patients with cancers who received chemotherapy.The factors which had significance(P0.05)were selected to be done by Logistic regression analysis.Results In univiriate analysis, the rate of hepatic and renal failure in group A was much higher than that in group B(P0.05).The myelosuppression rate in patients receiving radiotherapy or chemotherapy was higher than that in group B(P0.05).In multiviriate analysis,the rate in large dose of chemotherapy was significantely increased than that in group B(parameter estimation 2.58,OR14.13,P0.01).cytotoxic drugs,types of the chemotherapy drugs(OR(8.86),P0.01,parameter estimation 2.01).KPS score≤60, and metastasis of the bone or bone marrow(OR 3.16,P0.01,parameter estimation 1.37).These three factors had no significance The important risk factors of chemotherapy Conclusion The model can predictivly judge the probability of sever mylosuppression after chemotherapy.Then it can instruct the prophylactic growth factor administration.
【CateGory Index】: R730.5
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