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《Acta Academiae Medicinae Jiangxi》 2009-04
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Chronomodulated Chemotherapy of Oxaliplatin Combined 5-FU and CF Plus Levamisole on Colorectal Cancer of 41 Cases

SHI Fang a,LI Ling b,LI Chun-lai b,WU Jian-bing b,FENG Long b,JIANG Wei-min b(a.2006 Grade of Medical Department of Graduate School;b.Department of Oncology,the Second Affiliated Hospital,Nanchang University,Nanchang 330006,China)  
Objective To explore the therapeutic efficacy of chronomodulated chemotherapy of oxaliplatin combined 5-FU and CF(FFP)plus levamisole(LMS)on colorectal cancer.Methods 71 patients with advanced colorectal cancer were randomly divided into two groups.Experiment group(n=41)was employed the chronomodulated chemotherapy of FFP plus LMS:① Oxaliplatin(L-OHP)was injected at 15:00-17:00 in the first day;②5-FU was infused in sine velocity with an auto-infusion pump that controlled by a microcomputer from 22:00 of the first day to 10:00 of the next day with a concentration peak at 4:00,lasted 5 days;③ Leucovorin(CF)was infused before administration of 5-FU everyday,lasted 5 days,3~4 weeks repeatedly;④All patients received LMS 50 mg p.o.t.i.d.on days 1~3,every 14 days for 12 months.Control group(n=30)was treated by injecting L-OHP 150 mg/m2,CF 200 mg/m2 and 5-FU 500 mg/m2 respectively.The therapeutic efficacy and adverse drug reaction were investigated.Results The 1,2,3 year survival rate of experiment group and control group was 96.23%,71.10%,60.83% and 80.86%,67.38%,32.44%,respectively(P0.05).The 1,2,3 year TTP rate of experiment group was significantly lower than those of control group(58.26%,28.16%,28.16% vs 74.45%,58.22%,50.76%;P0.05).The percentage of adverse drug reactions had no significant difference between the two groups(P0.05).Conclusion The combination of chronomodulated chemotherapy of FFP with LMS may be more effective and may cause the lower adverse drug reactions on advanced colorectal carcinoma.
【CateGory Index】: R735.34
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1 LI zhi,ZHUANG Jing,HAN Guang sen,et al.Department of General Surgery,the Henan Provincal Tumor Hospital,Zhengzhou 450008,China;Influence of Levamisole on the Immune Function in Patients with Colorectal Cancer[J];Journal of Qilu Oncology;2003-10
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