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《Jiangxi Medical Journal》 2003-05
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The effect of Salvia Miltiorrhiza on Cardiomyocyte Apoptosis and Gene Protein Expression in Spontaneously Hypertensive Rats

Deng Jie,Xiong Wei,Zheng Zhi .(Intensive Care Unit,Zhou Shan Hospital,Zhejiang,Province,316004,China)  
Objective To observe the effect of Salivia Miltiorrhiza on cardiomyocyte apoptosis and gene protein expression in spontaneously hyperten-sive rats(SHR).Methods18male SHR were di-vided in3group at random(n=6):⑴the base group,which were killed in the8th week;⑵the Salvia Miltiorrhiza group,which Salvia Miltiorrhiza(1g /kg.d)were injected to intraperitoneally from the8th week to the18th week;⑶the control group,which the same volume of vehicle were injected in the same manner.The TUNEL method was employed to eval-uate cardiomyocyte apoptosis,and the immunohis to chemistry method was employed to detect the pro-tein expression of Bcl-2.Results Compared with the base group,cardiomyocyte apoptosis increased markedly in control group (P0.05),the positive ex-pression index of Bcl-2protein decreased signifi-cantly (P0.05),while the cardiomyocyte apoptosis decreased and the positive expression index of Bcl-2protein increased in the Salvia Miltiorrhiza group compared with the control group(P0.05).The cardiomyocyte apoptosis index showed negative cor-relationship with Bcl-2protein expression.Con-clusions The study show an age -dependent in-crease in apoptosis in the cardiac tissues of SHR.The chinese medicinal herb Salvia Miltiorrhiza can decrease the cardiomyocyte apoptosis and upregulat-ed the protein expression Bcl-2gene in SHR.
【CateGory Index】: R285
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