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《Jiangxi Medical Journal》 2006-05
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Inhibitory effects of flavone on gallstone formation and its mechanism in rabbits

Ye Deqiang, Ding Youming, Zhou Mingquan, et al(Department of hepatobiliary & laparoscopic Surgery,Renmin hospital of Wu Han university, Wu Han 430060, China)  
Objective To investigate the inhibitory effects of flavone from lotus leaf on experimental gallstone formation in rabbits. Methods 45 male New Zealand rabbits were divided into three groups:control group (n=15), lithogenic group (n=15) and flavone group (n=15) which were fed with the normal,1.2% high cholesterol and mixed (1.2% cholesterol and 0.4% flavone) diets for 4 weeks,respectively. RT-PCR was performed for APN gene expression in liver tissue. The leucine aminopepticlase and lipide in blood serum were chemically analyzed.Results Comparing with the negative results both in control and flavone prevention groups,cholesterol crystals and stones were found in 12 and 10 out of 15 gallbladders,respectively,under the polarizing microscope in lithogenic group. Stones were foud in 2 out of 15 in control group and 1 out of 15 in flavone group. The integrated opticasl density (IOD) ratio value of mRNA for APN gene was much higher in lithogenic group (1.16±0.12) than that in control and flavone prevention groups (0.72±0.24 and 0.86±0.38) respectively,(P0.05).TG,TC,LDL-C and ApoB were much higher in lithogenic group than those in control and flavone prevention groups (P0.01). HDL-C was much higher than that in control and flavone prevention groups (P0.05). However,ApoA was much lower in lithogenic group than that in control and flavone prevention groups(P0.05). Meanwhile,all indexes between the flavone and control group were not significantly different. Conclusion Flavone may prevent the gallstone formation through reducing the expression of APN in liver and LAP in serum and adjusting the lipid level in serum.
【Fund】: 国家科技攻关项目(2002BA546C);; 湖北省科技攻关重大项目(2002AA205A)
【CateGory Index】: R285.5
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