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《Jiangxi Medical Journal》 2006-05
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Inhibitory effects of flavone on gallstone formation and its mechanism in rabbits

Ye Deqiang, Ding Youming, Zhou Mingquan, et al(Department of hepatobiliary & laparoscopic Surgery,Renmin hospital of Wu Han university, Wu Han 430060, China)  
Objective To investigate the inhibitory effects of flavone from lotus leaf on experimental gallstone formation in rabbits. Methods 45 male New Zealand rabbits were divided into three groups:control group (n=15), lithogenic group (n=15) and flavone group (n=15) which were fed with the normal,1.2% high cholesterol and mixed (1.2% cholesterol and 0.4% flavone) diets for 4 weeks,respectively. RT-PCR was performed for APN gene expression in liver tissue. The leucine aminopepticlase and lipide in blood serum were chemically analyzed.Results Comparing with the negative results both in control and flavone prevention groups,cholesterol crystals and stones were found in 12 and 10 out of 15 gallbladders,respectively,under the polarizing microscope in lithogenic group. Stones were foud in 2 out of 15 in control group and 1 out of 15 in flavone group. The integrated opticasl density (IOD) ratio value of mRNA for APN gene was much higher in lithogenic group (1.16±0.12) than that in control and flavone prevention groups (0.72±0.24 and 0.86±0.38) respectively,(P0.05).TG,TC,LDL-C and ApoB were much higher in lithogenic group than those in control and flavone prevention groups (P0.01). HDL-C was much higher than that in control and flavone prevention groups (P0.05). However,ApoA was much lower in lithogenic group than that in control and flavone prevention groups(P0.05). Meanwhile,all indexes between the flavone and control group were not significantly different. Conclusion Flavone may prevent the gallstone formation through reducing the expression of APN in liver and LAP in serum and adjusting the lipid level in serum.
【Fund】: 国家科技攻关项目(2002BA546C);; 湖北省科技攻关重大项目(2002AA205A)
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 2 Hits
1 LIAO Li SHU Zhan LI Xiao-ran HAO Li-li School of Pharmacy,Medical College of Soochow University,Jiangsu;Research advance in chemical compositions and pharmacological actions of medicinal herbs related to lotus[J];Shanghai Journal of Traditional Chinese Medicine;2010-12
2 YANG Ji-yan1,2, HU Lei1,2,XU Yang1,2, (1.Sino-German Joint Research Institute, Nanchang University, Nanchang 330047, China; 2.Key Laboratory of Food Science, Ministry of Education, Nanchang University, Nanchang 330047, China);Research Progress of Flavonoids in Lotus Leaves[J];Food Science;2007-08
【Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Bo Liang 1, ZHONG Yue Xia 1, GU Bing Quan 2, CAO Yi Zhan 1, LU Jiang 1, TIAN Xiao Xi 1 1Department of Emergency, 2Department of Clinical Laboratories, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China;Application of leucine aminopeptidse in the diagnosis of hepatic diseases[J];Journal of The Fourth Military Medical University;2003-09
2 CHEN Xiang bai 1, ZHU Xue guang 1, ZHANG Hong jun 1, SHAO Li 2, WANG Xin hui 1, ZHAO Hua 1 (1. Department of General Surgery, Affiliated People's Hospital, Beijing Medical University, Beijing 100044, China; 2. Department of Physiology, Beijing;Isolation and purification of aminopeptidase N and promotion of nucleating activity in bile[J];CHINESE JOURNAL OF GENERAL SURGERY;2000-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Yue Ting 1, ZHU Xue Guang 1, CHEN Xiang Bai 1, ZHAO Xin Liang 2 (1.Department of General Surgery, Peking University People′s Hospital, Beijing 100044, China; 2.Department of Biochemistry and Molecular Biology,Peking University School of;The mechanism of the inhibitory effect of ursodeoxycholate on gallstone formation in rabbits[J];Journal of Beijing Medical University;2001-05
2 LI Qing-lin,YE Yue-hong,TANG Bo(Department of Clinical Laboratory,Second College of Clinical Medicine,Chongqing University of Medical Sciences,Chongqing 400010,China);Diagnostic value of multiple combined detection indexes in liver diseases[J];Chongqing Medicine;2007-10
3 Pan Xiaoliang, Song Chaohui, Liang Qiaomi Hangzhou First People’s Hospital, Hangzhou (310006);Study on Relationship Between the Serum Levels of Eight Biochemichal Items and Different Type of Hepatic Diseases[J];Journal of Radioimmunology;2007-06
4 YANG Ji-yong,ZHANG Jing-zhe.Department of Genneral Surgery,Longhua Hospital Affiliated to Shanghai University of TCM,Shanghai 200032,China;Clinical study on effects of Shengqing capsule on nucleoprotein α_1-acid glycoprotein and biochemical indicators of bile in patients with cholelithiasis[J];Journal of Hepatopancreatobiliary Surgery;2012-06
5 DING Youming1,YE Deqiang1,ZHOU Mingquan2,HU Zhongli3, SHEN Yang1 1Dept.of Hepatobiliary & Laparoscopic Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China 2Hubei Centre of Lotus Engineering Research,Wuhan 430072,China 3Centre of Lotus Research,Wuhan University,Wuhan 430072,China;Inhibitory Effects of Flavone from the Lotus on Gallstone Formation and Its Mechanism in Rabbits[J];Medical Journal of Wuhan University;2007-05
6 Song Wenhui. Yinzhou Second Hospital,Nibong 315100,China;The clinical significance of leucine aminopeptidse in the diagnosis of patients with chronic liver diseases infected HBV[J];Experimental and Laboratory Medicine;2008-01
7 ZHANG Kui,WEI HongXia,WANG Zhiqun,QIU Fang,WANG Li,GU Guangyu,LUO Xunyang(1.The Department of Medical Laboratory,2.The Department of Gynaecology and Obstetrics,Drum Tower Hospital Affiliated to Medical School of Nanjing University,Nanjing 210008,China);Clinical significance of diversity of serum LAP during pregnancy[J];Chinese Journal of Clinical Laboratory Science;2007-06
8 Chen Lin1,Fan Zhonglin2,Ni Runzhou3,et al.(1.Qinghai University Medical college;2.Qinghai University Affiliated Hospital of digestive internal medicine;3.Nantong University Affiliated Hospital of digestive internal medicine);STUDY ON THE VALUE OF SERUM LEUCINE AMINOPEPTIDASE ISOENZYME Ⅱ(LAP-Ⅱ) IN THE DIAGNOSIS OF PRIMARY HEPATIC CARCINOMA[J];Journal of Qinghai Medical College;2007-04
9 LI Yueting, ZHU Xueguang *. * Department of General Surgery, People's Hospital, Beijing University, Beijing 100044, P. R. China;Inhibitory effects of piperine on gallstone formation and its mechanism in rabbits[J];Chinese Journal of Hepatobiliary Surgery;2003-07
10 XU Manshan, ZHU Xueguang, LI Yueting. Department of Surgery, Peking University People′s Hospital, Beijing 100044, China;The activity of aminopeptidase N and gallstone formation[J];Chinese Journal of General Surgery;2001-08
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 DUAN Yu-qing1,2,ZHANG Hai-hui1,WU Jia2,XIE Bi-jun2(1.School of Biological and Environmental Engineering,Jiangsu University,Zhenjiang 212013;2.College of Food Science and Technology,Huazhong Agricultural University,Wuhan 430070,China);Differentiation of B16 Melanoma Induced by Proanthocyanidins from Lotus Seedpod[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-05
2 Jin Su-rong~1,Yao Li-feng~1,Li Hui~1,Yu Zuo-ping~2,Zhou Ming-quan~2,Hu Zhong-li~2 (1 School of science,Wuhan University of Technology,Wuhan 430070;2 Lotus center,Wuhan University,Wuhan 430072);Study on the extraction of flavonoids from lotus leaf and It′s antionxygenation[J];Anhui Agricultural Science Bulletin;2006-08
3 GUO Xue-feng et al (International Centre for Bamboo and Rattan, SFA Key Open Laboratory on Bamboo and Rattan Science and Technology, Beijing 100102);Research Advances in Extraction, Isolation, Purification and Content Determination of Methods Flavonoids[J];Journal of Anhui Agricultural Sciences;2007-26
4 YONG Guo-xin(College of Applied Technology,Haikou Economic Polytechnic College,Haikou,Hainan 570203);Study on Extraction Technique of Quercetin from Lotus Leaf[J];Journal of Anhui Agricultural Sciences;2008-14
5 JIN Su-rong~1,YAO Li-feng~1,LU Wei~1,YU Zuo-ping~2,ZHOU Ming-quan~2,HU Zhong-li~2(1 School of Science,Wuhan University of Technology,Wuhan 430070; 2 Lotus center,Wuhan University,Wuhan 430072,China);Research on the Extraction of Polyphenols from Lotus Leaf by Ultrasonic[J];Amino Acids & Biotic Resources;2006-03
6 FU Shuiyu, HUANG Aijin, LIU Huwei, SUN Yiliang (Department of Chemistry, Peking University)WU Qiang, XIA Yuyu (Analytical Center, Chinese People University);Studies of Flavor Components of Lotus Leaf (I) Analysis of Natural Flavor Components of Lotus Leaf[J];Acta Scicentiarum Naturalum Universitis Pekinesis;1992-06
7 YANG Ying1,2, LIU Bin1, BI Li-fu2, WANG Wei1, QI Qi-ge1,2, XIAO Shi-feng2 (1Beijing University of Chinese Medicine, Beijing100029,China; 2Inner Mongolia Medical College, Huhhot 010059,China);Effects of Jiangzhining on blood lipid regulation and anti-oxidation in hyperlipidemic rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-05
8 WANG Ji-sen,LIU You-ping,CHENG Bei,SHI Yu-hua,CHEN Hong-ping(School of Pharmacy,Chengdu University of TCM,Chengdu 611730,China);The Research on the Isolation and Identification of Hyperin in Receptaculum Nelumbinis and Quality Standard of Receptaculum Nelumbinis[J];Journal of Chengdu Medical College;2008-01
9 CHEN Jianfen1,HE Weihua2,QIAN Fugang2(1Shanghai Toothpaste Factory Co. LTD.,Shanghai200333,China;2Shanghai Institute of Pharmaceutical Industrial Research,Shanghai200040,China);Qualitative and quantitative analysis of bacteriostatic constituents of lotus leaf extract for mouth cavity[J];China Surfactant Detergent & Cosmetics;2003-01
10 ZENG Hong-yan,SU Jie-long,FANG Fang,FENG Bo (Biotechnology Research Institute,Xiangtan University,Xiangtan,Hunan 411105,China);Chemical Constituents of the Volatile Oils extracted from Lotus leaves with Different Methods[J];Acta Botanica Boreali-occidentalia Sinica;2005-03
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 WU Ye et al(Hanzhong Vocational and Technical College,Hanzhong,Shaanxi 723000);Effects of Different Extraction Conditions on Physico-chemical Quality of Lotus Leaf Tea[J];Journal of Anhui Agricultural Sciences;2012-14
2 Chen Xiujuan,Su Huiying,Wang Guangqin,Zeng Qiang,He Nian(Sichuan University of Science and Engineering,Material and Chemical Engineering Department,Zigong 643000,China);Aqueous Two-phase Extraction of Total Flavonoids from Lotus Leaves[J];Guangdong Chemical Industry;2011-12
3 WANG Jie1,2,CHEN Jun-peng1,2,CHEN Peng1,2,MA Jie1,2,GUO Fu-you1,2,YANG Chun-fen1,2,SHU Ding-ming1,2(1.Institute of Animal Science,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China;2.State Key Laboratory of Livestock and Poultry Breeding,Guangzhou 510640,China);Effects of Dietary Supplementation of Lotus Leaves Extract on Antioxidant Ability and Meat Quality of Yellow Broilers[J];China Animal Husbandry & Veterinary Medicine;2011-02
4 ZHU Xin-ting~1,DING Li-na~2,LIU Yun~3,LOU Fang-ming~4 (1.Basic Medicine School,Zunyi Medical College,Zunyi 563003,China; 2.Department of Pharmacy,Zunyi Medical and Pharmaceutical Junior College,Zunyi 563002,China; 3.Medical and Biological Research Center,Zunyi Medical College,Zunyi 563003,China; 4.Pharmacy School,Zunyi Medical College,Zunyi 563003,China);Comparative research on the chemical constituents of the volatile oil from ordinary powder and super-tiny powder of Nelumbo nucifera Gaertn leafves[J];Guangdong Agricultural Sciences;2012-15
5 SUN Dongmei1,2,CHEN Xueting2,LI Yangxue1,XU Aili1(1.Guangdong Provincial Institute of Traditional Chinese Medicine,Guangzhou 510095,China;2.Guangzhou University of Chinese Medicine,Guangzhou 510405,China);Study on HPLC fingerprint analysis of Nelumbo nucifera Gaertn[J];Journal of Guangdong Pharmaceutical University;2013-02
6 ZHONG Jiao-jiao,ZHANG Zhe,LI Wan-lin,FU Yong,DAI Hong-lin(College of Chemistry & Environmental Science,Shaanxi University of Technology,Hanzhong 723001,China);Study on Extraction of Alkaloids from Lotus Plumule[J];Technology & Development of Chemical Industry;2013-04
7 HUANG Wen1,WANG Ping1,HUANG Chi-fu2,LI Hai-zhou1(1.College of Life Science and Technology,Central South University of Forestry & Technology,Changsha 410004,Hunan,China;2.College of Dentistry,University of Kentucky,Lexington 40503,USA);Advance in research on antibacterial activity of extract in lotus leaf[J];Nonwood Forest Research;2010-02
8 JI BING,SONG TAO,XU CHENG-WEI,et al(Department of Anatomy,Qingdao University Medical College,Qingdao 266021,China);PROTECTIVE EFFECT OF NELUMBO FLAVONE ON MYOCARDIUM ISCHEMIA-REPERFUSION INJURY IN RAT[J];Medical Journal of Qilu;2009-06
9 YU Hao,RUAN Mei-juan,ZHAO Long,WANG Er-li (College of Food Engineering and Biotechnology,Tianjin University of Science and Technology,Tianjin 300457,China);Study on the Optimization of Ultrasonic Extraction Conditions of Flavonoids from Lotus Leaves Using Response Surface Methodology[J];Food Research and Development;2010-01
10 LI Song-lin(School of Food Engineering,Huaiyin Institute of Technology,Huai'an,223003,Jiangsu,China);Processing Technology of the Lotus Leaf Glutinous Rice Cake[J];Food Research and Development;2010-12
China Proceedings of conference Full-text Database 1 Hits
1 Ding Yaping,Ma Bianli,Yao Lifeng,Jin Surong School of Science,Wuhan University of Technology,Wuhan 430070,china;Study on HPLC Fingerprint of Lotus Leaves[A];[C];2012
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Bo Liang 1, ZHONG Yue Xia 1, GU Bing Quan 2, CAO Yi Zhan 1, LU Jiang 1, TIAN Xiao Xi 1 1Department of Emergency, 2Department of Clinical Laboratories, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China;Application of leucine aminopeptidse in the diagnosis of hepatic diseases[J];Journal of The Fourth Military Medical University;2003-09
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