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《Clinical Journal of Medical Officer》 2004-06
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Effects of Different Anesthetics on Hemodynamics and Plasma Glucose

Yan xiang-hua, Zhang Jia-ping (Department of Anesthesiology, the 18th Hospital of PLA, Yecheng 844900, China)  
Objective o evaluate the depression effects of propofol and thiopental and etomidate on stress response reflected by changes of hemodynamics and plasma glucose during the induction of anesthesia. Methods All the 43 patients who would undergoing operation under general anesthesia were at random divided into group Ⅰ (propofol, n=21) and group Ⅱ (thiopental, n=21) and group Ⅲ (etomidate, n=21). Propofol (2.5mg/kg), thiopental (5mg/kg) and etomidate 0.3mg/kg were administered for the induction of anesthesia respectively in group Ⅰ, Ⅱ and Ⅲ. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP) and heart rate (Hr) were recorded and plasma glucose level was examined before the induction (T 1), and immediately after prying into throat (T 2), and in 2min (T 3), 5min (T 4) and 15min (T5) after intubatton.Results The levels of plasma glucose of the three groups increased significantly at T 3~5 (P0.05 or P0.01). The level of group Ⅲ increased more significantly than that of group Ⅰ and Ⅱ (P0.01). The SBP, DBP and MBP increased more significantly in group Ⅱ and Ⅲ than in group Ⅰ at T 2~4 (P0.01 or P0.05P0.05). Conclusion The results suggest that propofol can blunt effectively the stress response induced by intubation.
【CateGory Index】: R614
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