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《Academic Journal of Pla Postgraduate Medical School》 2005-01
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Endotoxin-induced acute lung injury in rabbits and protective effects of fructose-1,6-diphosphate

XUE Qing-liang, WANG Jian-xin, JIANG Hong(Respiratory Department, PLA General Hospital, Beijing 100853, China)  
Objective:To study the effects of Fructose-1,6-diphosphate(FDP) on Endotoxin(ET)-induced acute lung injury(ALI) and the activities of phospholipase A 2(PLA 2) in rabbits. Methods:Japanese flap-eared white rabbits were randomly assigned to three groups: control group (group A), ET-treated group (group B) and combination group(treated by ET and FDP, group C).Acute lung injury was induced by the injection of ET at a time. During the experiment, respiratory rates, heart rates, blood pressure, arterial blood gases and the plasma PLA 2 activities were measured at 0h, 0.5h, 2h, 4h and 6h respectively. Then, after rabbits being killed at 6h, the pulmonary PLA 2 activities were measured, and the pathologic changes were examined with light microscope. Results:Compared with group A, rabbits of group B showed the typical characters of ALI, including respiratory rates and heart rates increasing, as well as blood pressure and arterial blood oxygen pressure decreasing. Significant increase of the PLA 2 activities was also seen both in blood serum and lung tissue in group B. Conditions in group C were better than those in group B. Conclusion:FDP can inhibit the PLA 2 activities, improves its pathologic physiological procedure, and possesses protective effects on early ALI in rabbits induced with ET.
【CateGory Index】: R563.8
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【References】
Chinese Journal Full-text Database 5 Hits
1 WANG Jian-xin,XUE Qing-liang,JIANG Hong(Respiratory Department,PLA General Hospital,Beijing 100853,China);Changes of procoagulant activities in acute lung injury and effects of fructose-1,6-diphos-phate[J];Academic Journal of PLA Postgraduate Medical School;2006-02
2 JIANG Hong, WANG Jian-xin, XUE Qing-liang(Respiratory Department, PLA General Hospital,Beijing 100853, China);Endotoxin-induced early acute lung injury in rabbits and the protective effects of chloroquine[J];Academic Journal of PLA Postgraduate Medical School;2006-03
3 LI Xin-fu, WANG Jian-xin, WENG Cui-lian(Respiratory Department of Medicine, PLA General Hospital, Beijing 100853, China);Study on endotoxin-induced acute lung injury and antagonizing effects of naproxen in rabbits[J];Academic Journal of PLA Postgraduate Medical School;2006-03
4 LI Xin-fu,WANG Jian-xin,WENG Cui-lian(Respiratory Department of Medicine,PLA General Hospital,Beijing 100853,China);Changes of MDA and SOD in endotoxin-induced acute lung injury in rabbits[J];Academic Journal of PLA Postgraduate Medical School;2007-05
5 WANG Jian-xin,GUO Li-na,GAO Qiang,WENG Cui-lian,SUN Jun-ping(Department of Respiratory,PLA Genaral Hospital,Beijing 100853,China);Study on endotoxin-induced acute lung injury and antagonizing effect of heme oxygenase in rabbits[J];Academic Journal of PLA Postgraduate Medical School;2008-03
【Citations】
Chinese Journal Full-text Database 1 Hits
1 WU Rong qian, SONG Xu hua, XU Ying xin, MENG Xian jun (Institute of Surgical Research, PLA General Hospital, Beijing 100853, China);The role of pro-and anti inflammatory cytokine in sepsis induced lung injury[J];ACADEMIC JOURNAL OF PLA POSTGRADUATE MEDICAL SCHOOL;2000-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 TIAN Jie,SONG Shao-gang,WANG Yu-ling,CHEN Zhi-wu,ZHAO Wei-zhong(Department of Pharmacology,Anhui Medical University,Hefei 230032,China);Effect of rutoside on phospholipase A_2 and Ca~(2+) in murine acute pancreatitis[J];Anhui Medical and Pharmaceutical Journal;2006-02
2 MENG Xiang-fei1,KOU Chang-gui1,LI Chun-ying2,SHI Jie-ping1,YU Qiong 1,MING Jian-guang,YU Ya-qin1(1.Research Center for Genomic Medicine,School of Public Health,Jilin University,Changchun 130021,China; 2.Department of Laboratory,Psychological Hospital of Changchun City,Changchun 130052,China);Association between serum phospholipase A2 activity and schizophrenia[J];Journal of Jilin University(Medicine Edition);2007-04
3 YANG Tian de 1,YANG Zong cheng 2,LUO Qi zhi 2,et al. (1 Department of Anesthesology,Xinqiao Hospital;2 Research Institute of Burns,the Third Military Medical University, Chongqing 400037,China);The changes of mRNA expression and activity of pulmonary low molecular phospholipase A_2 in rats after smoke inhalation injury[J];Chongqing Medical Journal;2004-04
4 YANG Tian-de 1,YANG Zong-cheng 2,LUO Qi-zhi 2 (Department of Anesthesiology,Xinqiao Hospital,the Third Military Medical University,Chongqing 400037,China);Parimary study on the change of 85_(KD) phospholipase A_2 in lung tissue of rats with smoke inhalation injury[J];Chongqing Medical Journal;2004-10
5 LI Ping, LU Song-ming , LI Zhu , et al. (Research Institute of Surgery, Third Military Medical University, Chongqing 400042. China);Protective effect of dexamethasone-the inhibitor of phospholipase A_2 on endotoxemia animals[J];Journal of Traumatic Surgery;2001-02
6 Wang Dongji,Shang Gaiping,LianWeimin Department of Physiology,Changzhi Medical College;The Protective Effects of Ligustrazine on Acute Cerebral Ischemia-Reperfusion Damages in Rabbits[J];Journal of Changzhi Medical College;2003-04
7 Guang-Fu Cheng, Pei-lan Yu, Li-Min Jin, et al. Department of Pediatrics, Shenzhen City Red Cross Hospital, Shenzhen 518029;Effect of baicalin and tetramethylpyrazine on infectious brain edema and phospholipase A 2 in rabbits[J];CHINESE JOURNAL OF CONTEMPORARY PEDIATRICS;1999-03
8 Li Shaohua, Chen Sifeng, Fei Xia, Ding Ziqiang, Wu Zhongli (Department of Pathophysiology, Department of Training, Shanghai, 200433);Platelet-activating Factor Mediates Endotoxin-induced Lung Injury in Dogs and Its Mechanism[J];Academic Journal of Second Military Medical University;1992-02
9 Fan Jie, Xu Renbao (Department of Pathophysiologv .Shanghai,200433);The Development and Study of the Glucocorticoid Receptor Blockade Animal Model[J];Academic Journal of Second Military Medical University;1993-01
10 WANG Zhi Nong *,ZENG Zhi Yong,HE Bin,ZHANG Bo,XU Zhi Yun,HUANG Sheng Dong,ZHANG Bao Ren(Department of Cardiothoracic Surgery,Changhai Hospital,Second Military Medical University,PLA Institute of Cardiothoracic Surgery,Shanghai 200433,China);Effect of ischemic preconditioning on myocardial cell membrane fluidity before and after feline cardiopulmonary bypass[J];Academic Journal of Second Military Medical University;2004-04
China Proceedings of conference Full-text Database 3 Hits
1 Zhu Jing-tong,Zheng Zhi-hui,Lu Xin-hua,Fan Yu-ling,Zhang Hua,He Jian-gong(New Drugs Research & Development Center of North China Pharmaceutical Group Corporation,National Microbial Medicine Engineering & Research Center,Shijiazhuang 050015);A fluorescence-based method on the high throughput screening assay for PLA2 inhibitor in vitro[A];[C];2008
2 GAO Bin, GAO Hong, YAN Yu-lin, (College of Food Science and Technology, Yunnan Agricultural University, Yunnan, Kunming, 650201, China ;College of Animals Science and Technology, Yunnan Agricultural University, Yunnan, Kunming, 650201, China);Alteration of Endotoxin on Phospholipase A_2 Activities of Biomembrane and Cation A Antagonism in Rabbits[A];[C];2006
3 Wei Qingyu, Department of Allergy Diagnsis,No.202 Hospita of Shenyang Military Area, Shenyang 1 10003, Li Gang, Department of Intemal Medicine of Liaoning College of TCM;The expression of asthma white rat bronchus epithelia ICAM-1 and the effect of content of IL-5 in BALF by prescription and medicine of strengthening spleen and benefiting Vital Qi[A];[C];2002
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 FENG Ying kai,XU Jian cheng,YANG Qing hua,et al. (1.Institute of Respiratory Disease of P.L.A,Xinqiao Hospital,the Third Military Medical University, Chongqing 400037,China;2.Chongqing Health luformation Center,Chongqing 400014,China);Th1/Th2 shift and its effects in lipopolysaccharide-induced acute lung injury in rats[J];Chongqing Medical Journal;2004-07
2 Ming Mei,Meng Xiang-zhi(Department of Forensic Medicine,School of Medicine,Wuhan University,Wuhan430071,China);Immunohistochemical observation of heart-type fatty acid binding-protein in early myocardial ischemia[J];Journal of Forensic Medicine;2004-01
3 Wang Xiaoyuan, Xia Zhongyuan, Du Daping,et al Department of Anesthesiology, Renmin Hospital, Wuhan University, Wuhan 430060, China;Role of HO-1/CO in Lipopolysaccharide-induced Acute Lung Injury and the Effect of Sodium Nitroprusside on It[J];Journal of Hubei Medical University;2005-01
4 Jiang Hong, Wang Jianxin, Xue Qingliang. General Hospital of PLA, Beijing 100853, China;The role of phospholipase A_2 in the pathogenesis of endotoxin-induced acute lung injury and the protective effects of chloroquine in rabbits[J];Medical Journal of Chinese People's Liberation Army;2004-11
5 Wang Jianxin,Weng Cuilian,Xue Qingliang,et al.Department of Respiratory Diseases,General Hospital of PLA,Beijing 100853,China;Changes in IL-19 and antagonizing effects of meloxicam on endotoxin-induced acute lung injury in rabbits[J];Medical Journal of Chinese People's Liberation Army;2007-04
6 JIE Zhijun, LUO Yong, XU Weiguo,LIN Jianhai,SONG Zhifang,CAI Yingyun. Department of Pulmonolgy, Xinhua Hospital, Shanghai Second Medical University,Shanghai 200092,China;Changes of serum neutrophil elastase activity in patients with acute lung injury[J];Journal of Emergency Medicine;2005-06
7 ZANG Xiuxian,DONG Junshu,LI Xiujiang.Department of Emergency Medicine,The First Hospital of Jilin University,Changchun 130021,China;Change of oxygen free radicals on the myocardial injury in acute multiple organ dysfunction syndrome(MODS)[J];Chinese Journal of Emergency Medicine;2006-02
8 JIANG Hong, WANG Jian-xin, XUE Qing-liang(Department of Respiratory Medicine, PLA General Hospital, Beijing 100853, China);The role of phospholipase A_2 in endotoxin-induced acute lung injury in rabbits[J];Academic Journal of Pla Postgraduate Medical School;2004-05
9 LI Xin-fu, WANG Jian-xin, WENG Cui-lian(Respiratory Department of Medicine, PLA General Hospital, Beijing 100853, China);Study on endotoxin-induced acute lung injury and antagonizing effects of naproxen in rabbits[J];Academic Journal of PLA Postgraduate Medical School;2006-03
10 WANG Ming-hai , ZHANG Yi-sheng, ZHAO Guo-hai, SHI Hai-sheng, JIANG Yong, TAO Kun, HAN Guang-feng, WU Jing-yi Department of General Surgery, Yijishan hospital, Wannan Medical College, Wuhu 241001;The change of pulmonary MDA and MPO induced by early-stage severe acute pancreatitis in rats[J];Acta Academiae Medicinae Wannan;2006-02
【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 WENG Cui-lian, WANG Jian-xin, LI Xin-fu, GAO Qiang(Respriratory Department, PLA General Hospital, Beijing 100853, China);Pulmonary PPAR-γ protein expression of endotoxin-induced acute lung injury and effects of meloxicam in rabbits[J];Academic Journal of PLA Postgraduate Medical School;2007-02
2 WANG Jian-xin,WENG Cui-lian,LI Xin-fu,XUE Qing-liang,GAO Qiang,GUO Li-na(Respriratory Department,PLA General Hospital,Beijing 100853,China);Changes of ACE and ET-1 in endotoxin-induced acute lung injury and antagonistic effects of meloxicam in rabbits[J];Academic Journal of PLA Postgraduate Medical School;2007-03
3 LI Xin-fu,WANG Jian-xin,WENG Cui-lian(Respiratory Department of Medicine,PLA General Hospital,Beijing 100853,China);Changes of MDA and SOD in endotoxin-induced acute lung injury in rabbits[J];Academic Journal of PLA Postgraduate Medical School;2007-05
4 WANG Jian-xin,GUO Li-na,GAO Qiang,WENG Cui-lian,SUN Jun-ping(Department of Respiratory,PLA Genaral Hospital,Beijing 100853,China);Study on endotoxin-induced acute lung injury and antagonizing effect of heme oxygenase in rabbits[J];Academic Journal of PLA Postgraduate Medical School;2008-03
5 GUO Li-na,WANG Jian-xin,GAO Qiang,WENG Cui-lian,LI Xin-fu,SUN Jun-ping(Department of Respiratory,Chinese PLA Genaral Hospital,Beijing 100853,China);Changes of serum neutrophil elastase concentration and interferential effects of hemin in acute lung injury in rabbits[J];Academic Journal of PLA Postgraduate Medical School;2008-05
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