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《Academic Journal of PLA Postgraduate Medical School》 2006-05
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Experimental study of healing process following sutureless adhesive anastomosis of carotid endarterectomy

LIANG Chun-yang,ZHOU Ding-biao,YU Xin-guang,ZHANG Wen-bin,WANG Shi-bo(Department of neurological surgery,PLA General Hospital,Beijing 100853,China)  
Objective:To observe the healing process following sutureless adhesive anastomosis of carotid endarterectomy(CEA).Methods:Using New Zealand rabbits,carotid atherosclerotic stenosis(CASS)model were created by air-drying an isolated seagment of common carotid artery and feeding high cholesterol diet for 2 months.The formation of neointima were observed at 4hours,1,3,7,30,90days by ultrasound and angiography and pathology after CEA.Results:Several stages could be seen in formation of neointima after CEA.The thrombosis could be seen from several hours to 3 days after CEA;the inflammation took place with thrombosis;new endothelium began to grow from the surrounding over the thin thrombus at 3 days after CEA;vascular Smooth muscle cell(VSMC) began to proliferate in local media at 3 days;the formation and stacking of extracellular matrix(ECM) began.Conclusion:New sutureless adhesive anastomosis is a new reliable method for the vessel reconstruction of carotid endarterectomy.
【Fund】: "十五"国家科技攻关计划重大疾病防治研究项目资助课题(2001BA703B16)
【CateGory Index】: R651
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