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《Academic Journal of Chinese PLA Medical School》 2014-08
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Effect of zinc on the phosphorylative ERK expression in capsaicin induced neuropathic pain in mice spinal cord and hot pain threshold

WANG Yue-jing;LIU Xiao-lu;LI Fu-xing;HAN Yan-xiu;ZHANG Li;Department of Histology and Embryology, Liaoning Medical College;  
Objective To observe the effect of zinc on the expression of phosphorylative extracellularsignal-regulate kinase(pERK) in spinal cord and the hot pain threshold of capsaicin induced neuropathic pain(NPP) in model rats. Methods Seventy two C57/BL6 rats were randomly divided into 4 groups and capsaicin(0.5%, 5 μl) was injected in feet of NPP rats to build the model. Control group: normal(zinc, 30 mg/(kg·d)) fed rats injected with solvent(Tween 80, alcohol and 0.9% sodium chloride solution); N-NPP group: normal fed rats were injected with capsaicin after 2 weeks; L-NPP group: low-zinc(0.85 mg/(kg·d)) fed rats were injected with capsaicin after 2 weeks; H-NPP group: high-zinc(227mg/(L·d)) fed rats were injected with capsaicin after 2 weeks. Animal ethology observation, immunohistochemistry, immune blotting and image analysis were used to test the effect of zinc on the expression of pERK in model mice spinal cord and the hot pain threshold during seven days after injection. Results High-zinc feed could down-regulate the pERK expression, improve the hot pain threshold(P0.01), while low-zinc feed can up-regulate the pERK expression, reduce the hot pain threshold(P0.01). Conclusion Zinc can inhibit the pERK expression in spinal cord and the hot pain threshold of capsaicin induced NPP in model rats.
【Fund】: 国家自然科学基金项目(81171799);; 辽宁省科技厅资助项目(20111118);; 辽宁医学院奥鸿大学生创新基金(2011D17);; 辽宁医学院横向课题(LYHX2013025);; 辽宁医学院奥鸿博泽研究生科研创新基金(2012009);; 辽宁省大学生创新训练计划项目(201210160007)~~
【CateGory Index】: R741
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