The observation of synovialis of facet joint of cervical spine in pathological aspect and its relevance to the pathogenesis of spondylopathy
YU Qing-sheng 1, ZHONG Yan-feng 1, SUN Yu 2,et al. (1.Department of Pathology Peking University; 2.The Third Affiliated Hospital of Peking University, Beijing 100083,China)
Objective In order to study relevance of the pathological morphology of synovialis of facet joint of cervical spine to cervical spondylopathy. Methods We resort to routine pathologic methodology, immunohistochemistry,immunofluorescence and ethylaldehyde acid-induced biomonoaminic fluorescence. Results The authors discover that the pathologic morphology of cervical spondylopathy is mainly inflammation, thickening of synovialis through fibrosis and adiposation, exudation of fibrin, mucous degeneration, infiltration of lymphocytes, macrophages, and neutrocytes, hyperplasia and inflammation of vessels and degeneration of musculature adjacent to the synovialis. Through immunohistochemistry, immunofluorescence and ethylaldehyde acid-induced biomonoaminic fluorescence, we discovered neuropeptide Y-positive fibers, ethylaldehyde acid reactive fibers and calcitonin gene-related peptide-positive fibers that suggest the existence of sympathetic fibers as well as nociceptive fibers in the synovialis of cervical spine. At the same time, some inflammatory factors such as IgG and C 3 are found in the synovialis of cervical spine. Conclusion Through the authors' work, the existence of sympathetic fibers, some nociceptive fibers and inflammation in the synovialis of facet joints of cervical spine are corroborated.
【CateGory Index】： R681.55