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《Journal of Military Surgeon in Southwest China》 2006-01
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Effects of Basiliximab on the Serum IL-2 and Serum Scr of Kindney Transplantation Recipients

ZHU Dong-feng,WANG Yue,ZHEN Shou-hua,The First Attatched Hospital to Zhenzhou University,Zhenzhou,Henan Province,476400  
Objective To analyze the effects of basiliximab on the serum IL-2 and serum SCr of kidney tranplantation recipients and evaluate its validity and security.Methods 72 kidney transplantation recipients were randomly divided into two groups:the basiliximab group(n=37 and the control group(n=35).All the patients were treated by the combination of CsA+MMF+Pred;the basiliximab group were treated by basiliximab(1.0mg/kg)2h before transplantation and 4days after transplatation;serum IL-2 and serum SCr were detected and AR adverse reaction was observed.Results Serum IL-2 and serum SCr in the basiliximab group were much lower than that in the control group(P0.05);AR was found in 12 patients:3 in the basiliximab group and 9 in the control group(P0.05).Conclusions Basiliximab can reduce the level of serum IL-2 serum SCr and ratio of AR evidently and there is a little adverse reaction,so it is a strong and safe immunosuppressant.
【CateGory Index】: R699.2
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