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《Chinese Journal of Laboratory Medicine Education》 2004-Z1
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The changes of immature reticulocyte in experimental benenze poisoning

LU Hong ,WANG Mingshan. WenZhou Medical College, WenZhou 325000.  
objective:To investigate the changes of immature reticulocyte fraction (IRF) in chronic benzene poisoning.Methods: Reproduce aplastic anemia mice model of chronic benzene poisoning.The investigation included control group (A) and test group (B), 32mice in each group, averagely divided into 4 subgroups.Group A were injected subcutaneously in dorsal region with corn oil(2ml/kg),three times a week.For the different injection times they were divided into groupAl (15times)、groupA2 (18times)、groupA3 (21 times )、groupA4 (24times).Test Group (B) had the same method with the Control Group except injection with benzene and corn oil mixture (2mi/Kg), The IRF、percent of reticulocyte (Ret%)、mean reticulocyte volume (MRV)、white blood cell (WBC)、platelet (PLT)、red blood cell (RBC) and hemoglobin (HBG) of every group were detected by Beckman—Coulter Gen.S Auto Hematology Analyzer.The results were analyzed and compared between the test group and the control group correspondingly.Results: At 15th injection, compared with the control group, test group showed a significant reduction in WBC、MRV (P0.01 or P0.05 respectively); at 18th times, Test group showed a significant reduction in IRF and PLT simultaneously (P0.01) ; at 21st times,RET% decreased slightly (P0.05), IRF decreased greatly (P 0.001), other parameters decreased variously (P0.01 or P0.001) ; at 24 th times, Test group showed a significant reduction in all parameters (P0.01orP0.001).Conclutions:In the aplastic anemia model of chronic benzene poisoning IRF and MRV decreased earlier than other erythrocyte parameters.The authors conclude that IRF and MRV valuable parameters for reflecting marrow restraint.
【CateGory Index】: R446.1
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