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《Laboratory Medicine and Clinic》 2013-16
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Evaluate the value of anti-cyclic citrullinated peptide antibody and rheumatoid factor in the diagnosis of rheumatoid arthritis

MO Qiao-xuan,ZHANG Jian-xia,ZHANG Jin-feng,SU Rong(Department of Clinical Laboratory,Chinese Medicine Hospital of Foshan,Foshan,Guangdong 528000,china)  
Objective Evaluate the diagnosis value of anti-cyclic citrullinated antibody(anti CCP antibody)combined with rheumatoid factor(RF) for rheumatoid arthritis(RA).Methods From May 2011 to September 2011,202 patients with rheumatic disease were selected,including RA group,and non-RA group.The quantitative chemiluminescence method to detect anti-CCP antibody,immune turbidimetric assay to test RF,and the results were analyzed statistically.Results The diagnostic test sensitivity of anti-CCP antibody,specificity,positive and the negative predictive value were,78%,80.6%,82.5%,75.8%;RF:89.9%,52.7%,69%,81.7%.To analyze parallel and series test after anti-CCP antibody combined with RF detection,The above indexes were,parallel:93.6%,51.6%,69.4%,87.3%;series:74.3%,81.7%,82.7%,73.1%;The result of comparison in the RA group sensitivity:RF and anti-CCP antibody+RF series testing compared to individual CCP testing was significantly different(P0.05),Beside,Anti-CCP antibody+RF parallel testing and RF testing was significantly different(P0.05).In the mean of anti-CCP antibody and RF positive results,RA group and RA group was significantly difference.Conclusion Detection of anti CCP antibody Combined with RF could provide clinical diagnosis for RA than individual testing.It could avoid leakage diagnosis caused by the low anti-CCP antibody sensitivity,and misdiagnosis caused by RF low specificity,and provided the basis for clinical early diagnosis.
【CateGory Index】: R593.22
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