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《Laboratory Medicine and Clinic》 2016-13
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Distribution characteristics of elevated serum CEA and CA199 in benign and malignant diseases

WANG Tao;LIANG Li;ZHANG Yanling;WANG Xiaohuan;ZUO Changjing;Department of Nuclear Medicine,Changhai Hospital,Second Military Medical University;  
Objective To investigate the distribution characteristics and auxiliary diagnostic value of elevated serum CEA and CA199 in patients with benign and malignant diseases.Methods A total of 509 inpatients with both elevated serum CEA and CA199 level were chosen,and the related data were analyzed retrospectively with SPSS18.0.Results In all 509 patients,malignant tumor patients and benign diseases patients accounted for 77.21%and 22.79%respectively,and the levels of CEA and CA199 both had significantly statistics differences between the two groups(P0.05).The patients with pancreatic cancer were with lower CEA level compared with those with lung carcinoma,colorectal cancer,gastric carcinoma or breast cancer(P0.05),but with higher CA199 level compared with those with lung carcinoma or hepatic carcinoma(P0.05).When taking 10ng/mL and 90U/mL as cut-off value of CEA and CA199,the differences between the two groups emerged(P0.05).Conclusion Benign diseases could increase serum CEA and CA199 levels.Meanwhile,CEA≥10ng/mL or CA199≥90U/mL might provide valuable information for the differential diagnosis of benign and malignant diseases.
【Fund】: 国家自然科学基金资助项目(81170435);; 新一轮上海市卫生系统优秀学科带头人培养计划基金项目(XBR2011040);; 长海医院1255学科建设计划特色提升项目(CH125521103)
【CateGory Index】: R730.43
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