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《Laboratory Medicine and Clinic》 2018-04
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The value of endoscopic ultrasound-guided fine needle aspiration combining with immunohistochemistry in solid mediastinal lesions

XIANG Guoqing;ZHU Jia;GAO Na;Department of Endoscopy,Cancer Hospital of China Medical University/Liaoning Cancer Hospital &Institute;  
Objective To evaluate the value of esophageal endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)combing with immunocytochemistry(IHC)in patients with solid mediastinal lesions.Methods A total of 83 patients with solid mediastinal lesions were diagnosised by EUS-FNA consecutively,the results of cytology,histology and immunohistochemistry were analyzed retrospectively.Results A total of 79 patients(95.2%)were diagnosed by EUS-FNA finally,including malignant tumor 72 cases and benign tumor/tuberculosis 7 cases.The sensitivity,specificity,accuracy,positive predictive value,negative predictive value for EUS-FNA of mediastinal malignant tumor in patients were 94.7%,100.0%,95.2%,100.0%,63.6%,respectively.39 cases(49.4%)were diagnosed by immunohistochemistry,of which 32 were lung cancer,accounting for 50.8%(32/63)of all lung cancer.Conclusion EUS-FNA joint immunohistochemical can improve the accuracy of the diagnosis in solid mediastinal lesions,especially for precision classification in lung cancer with mediastinal metastasis.
【CateGory Index】: R445.1;R734.5
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