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《Journal of Preventive Medicine of Chinese People's Liberation Army》 2007-05
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EFFECT OF CHINESE MEDICINE—LGQX ON HYPOXIA-TOLERANCE AND ISCHEMIA OF MYOCARDIUM

Zhao Yun,Xu Da,Yi Dan,Wu Lei,Yang Zhi-hua,Qian Ling-jia(Institute of Hygiene and Environmental Medicine,Academy of Military Medical Sciences,Tianjin 300050,China)  
Objective To study the effects of Chinese medicine—Lianguiqingxin(LGQX) on hypoxia tolerance and acute myocardial ischemia,so as to provide pharmacological basis for further clinical study.Methods Hypoxia tolerance test was performed by placing the mice into a closed bottle to measure their survival time.Myocardial infarction model was made by ligation of left anterior descending coronary artery of rats,and myocardial infarction area(MIA),changes of ECG and segment ST,as well as myocardial enzyme activity were observed.Results Both 2.40 and 4.80 g·kg-1·d-1 of LGQX could prolong survival time of mice under closed hypoxia condition((974.0±59.5)s,(1004.8±125.5)s respectively vs(861.8±114.5)s,P0.05).The MIA in 2.40 g·kg-1,and 4.80 g·kg-1 group were reduced by 36.8%(P0.01),58.1%(P0.01) respectively.The elevation of ST segment in ECG at different time points,and the decrease in activities of serum AST,LDH,CK-MB were also observed(P0.05) in acute myocardial infarction rats treated with LGQX(1.20~4.80 g·kg-1·d-1). Conclusion LGQX can enhance anti-hypoxic effect of mice,and has obvious protective effect on ischemic myocardium.
【Fund】: 天津市科技发展计划项目课题(No.043180711)
【CateGory Index】: R285.5
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