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《Journal of Preventive Medicine of Chinese People's Liberation Army》 2007-05
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Zhao Yun,Xu Da,Yi Dan,Wu Lei,Yang Zhi-hua,Qian Ling-jia(Institute of Hygiene and Environmental Medicine,Academy of Military Medical Sciences,Tianjin 300050,China)  
Objective To study the effects of Chinese medicine—Lianguiqingxin(LGQX) on hypoxia tolerance and acute myocardial ischemia,so as to provide pharmacological basis for further clinical study.Methods Hypoxia tolerance test was performed by placing the mice into a closed bottle to measure their survival time.Myocardial infarction model was made by ligation of left anterior descending coronary artery of rats,and myocardial infarction area(MIA),changes of ECG and segment ST,as well as myocardial enzyme activity were observed.Results Both 2.40 and 4.80 g·kg-1·d-1 of LGQX could prolong survival time of mice under closed hypoxia condition((974.0±59.5)s,(1004.8±125.5)s respectively vs(861.8±114.5)s,P0.05).The MIA in 2.40 g·kg-1,and 4.80 g·kg-1 group were reduced by 36.8%(P0.01),58.1%(P0.01) respectively.The elevation of ST segment in ECG at different time points,and the decrease in activities of serum AST,LDH,CK-MB were also observed(P0.05) in acute myocardial infarction rats treated with LGQX(1.20~4.80 g·kg-1·d-1). Conclusion LGQX can enhance anti-hypoxic effect of mice,and has obvious protective effect on ischemic myocardium.
【Fund】: 天津市科技发展计划项目课题(No.043180711)
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 2 Hits
1 LIU Lu-jiong,WANG Xiao-long (Department of Cardiology,Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China);Applications of heat-clearing and detoxicating method in the treatment of coronary heart disease[J];World Clinical Drugs;2009-09
2 LIN Hua1,QU Xiang-zhi2,LI Jia2,CHEN Zheng-ai2(1.Department of Electrodiagnostics,The Second People's Hospital of Yanbian;2.Department of Pharmacology,Yanbian University College of Basic Medicine:Yanji 133000,Jilin,China);Protective effects of the Flos lonicerae compound preparation on acute myocardial ischemia in mice[J];Journal of Medical Science Yanbian University;2011-02
Chinese Journal Full-text Database 4 Hits
1 CHEN Shi-hong~1 YE Yun~2 SHANG Zheng-lu~3 WEI Hong-chang~4 SHANG Yun~2 YAN Shi-yun~4 1.Taizhou Central Hospital,Zhejiang;2.Guangming Hospital of TCM,Nanhui,Shanghai;3.Qinghai Province Cardiology Hospital;4.Shanghai Univercity of TCM;Counterevidence Study on Syndrome Pattern of Rats of Acute Myocardial Ischemia with Different TCM Treatments[J];Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai;2005-04
2 LHO Han-Chuan, HUANG He-Qing, LIU Xiao-Xia, CHEN Jian-Ping, TAN Hong-Mei, YANG Hui, TANG Tie-Jun, LIANG Tian-Wen,WU Wei-Kang Department of Pathophysiology, Sun Yat-sen University of Medical Sciences, Guangzhou (510089);Experimental research on the protective effect of SiNi decoction on acute ischemic myocardium[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1999-11
3 FU Xiaochun1, WANG Minwei1, LI Shaopeng2, CAO Lili1( 1.School of Ph armacy , Shenyang Pharmaceutical University, Shenyang 110016; 2.Department of Brai n Neurosurgery, China Medical University, Shenyang 110016, China);Experiment Study of Folium Bambusae Extraot Against Hypoxia[J];Traditional Chinese Drug Research & Clinical Pharmacology;2005-02
4 Gu Wanli,Shi Zaixiang China-Japan Fredship Hospital(Beijing 100029));The Non-circulatory Mechanism of Traditional Chinese Herbs in Protecting Myocardial Ischemic Injury[J];Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease;2005-05
Chinese Journal Full-text Database 10 Hits
1 HUANG Cai-yun 1, HUANG Sheng-ying 1, XIE Shi-rong 1, GAO Guang-you 2 (1 Department Pharmacology Medicine of Dalian Univesity, Dalian 116622 China;2.Department of Pharmacology,Dalian Medical University,Dalian 116027 China);Experimental studies on antiarrhythmic effects of oxymatrine[J];Journal of Dalian Medical University;2001-04
2 JIAO Shu-ping,ZHOU-Wei,XUE Li-juan(Department of Biochemistry,Medical College of Beihua University,Jilin 132013,China);Protective effect of the polyphenols of vitis amurensis Rupr on rat heart mitochondria injury induced by oxygen stress[J];Chinese Journal of Control of Endemic Diseases;2008-01
3 Liu Lianpu; Shan Chunwen; Liu Xihong;Xiao Huancai;Yang Shuqin; An Lianbing (Department of Electron Microscopy, Department of Pharmacology, First Military Medical University,Guangzhou, 510515; Department of Electron Microscopy,Guangzhou Medical College,Gua;Effects of Polydatin on the ultrastructure of platelets[J];Journal of First Military Medical University;1998-02
4 He Wei, Zhu Zuenping Department of Pharmacology, Gannan Medical College, Ganzhou (341000);Effect of Panax Notoginseng Saponins on the Content of IL-8 in Serum After Cerebral Ischemia-Reperfusion in rat[J];Journal of Radioimmanology;2002-05
5 WANG Xi-sha,TAN Yu-zhi,PAN Xue-diao,ZHANG De-zhi(School of Pharmacy,Guangdong Pharmaceutical College,Guangzhou,Guangdong 510006,China);Experimental study of anti-myocardial ischemia effect of sodium ozagrel[J];Journal of Guangdong Pharmaceutical College;2010-03
6 LIU Feng,HUANG Wei -min, ZHANG Li,LI Qing-yun, WU Jian-yun,XINZhi-fei ( The Geriatric Department, The First Municipal People's Hospital of Guangzhou , Guangzhou 510180, China);Observation of the adverse effects incurred from lower heart rate by large dose moteprolol tablet in the elderly patients with unstable angina pectoris[J];The Chinese Journal of Clinical Pharmacology;2006-03
7 Long Shengjing, Xie Yunfeng, Qin Aijuan, et al (Department of Chemistry);A STUDY ON ANTI-ACTIVE OXYGEN EFFECT OF SEVEN CHINESE PATENT MEDICINES FOR CARDIO-VASCULAR DISEASES[J];;1993-01
8 Yang Hailu Department of Pathophysiology,Hubei Medical College,Wuhan,China;An Experimental Study on Protective effect of Trichosanthes on Acute Myocardial Infarction-Reperfusion[J];;1991-02
9 SHU Shimin, LU Di, ZHANG Zenghui, et al.Department of TCM with Western medicine,The First Central Hospital of Baoding, Hebei, Baoding 071000;Therapeutic effect of Fufangshuanghua decoction on CRP and WBC of coronary atherosclerotic cardiopathy[J];Hebei Journal of Traditional Chinese Medicine;2008-02
10 ;Study Progress in Treatment of Artherosclerosis With Chinese Herbs[J];Guiding Journal of TCM;2005-11
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 WU Ding-hong1,QIU Xiao-hui1,ZHU Wei1,YUAN Xiao-hong1,ZHAO Rui-zhi1,XU Xiao-jie1,2(1The Second Clinical Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510120,China;2College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China);Study on mechanism of clearing-heat herbs on coronary disease in molecular level by network pharmacology[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-05
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Gao Chengxian,Ding Zhishan,Wo Xingde,et al Zhijing College of TCM,Hangzhou(310053);Exper imental Study of Xufu Zhuyu Tang on Anti myocardial lschemia and Hypoxia Tolerance[J];Journal of Zhejiang College of Tcm;2001-02
2 Du Li { Second Affiliated Hospital, Medical School of Shantou University, Guangdong);Effects of Modified Zhengwu Decoction on Cardiac Muscle Cell Apoptosis in Rabbit with Congestive Heart - Failure[J];China Journal of Traditional Chinese Medicine and Pharmacy;2000-02
3 TAN Hong-mei, CHEN Jian-ping, WU Wei-kang, LUO Han-chuan, QIAN Xiao-xian, LIANG Tian-wen, ZHOU Ling, LU Li Department of Pathophysiology, Sun Yat-Sen University of Medical Sciences, Guangzhou 510089, China;Protective effect of compound XueShuanTong capsule on experimental ischemic myocardium of canine[J];Journal of First Military Medical University;2000-03
4 Liu Xiao Chun,Liu Zheng Xiang1,Shi Jing,Shi Jing ( Departmentof Neurobiology,1Departmentof cardiology of Tongji H ospital, Tongji Medical University,Wuhan 430 0 30 China,China);EXPERIMENTAL STUDY ON THE EFFECTSOF RADIX GINSENG RUBRA ON CARDIOMYOCYTE APOPTOSISAFTER ISCHEMIA AND REPERFUSION IN RATS[J];CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY;2000-03
5 CHEN Xiang, WEN Xiao dan, ZENG Shan, et al. (Department of Anatomy, Xiangya Hospital, Central South University, Changsha 410078,China);Protective effect of ginsenoside on cardiomyocytes during cardiac surgery: an ultrastructural study by morphostereology[J];Bulletin of Hunan Medical University;2002-05
6 Yu Lei Wang Zhigang Ma Yingzhong Institute of Cardiovascular Function Research,Wannan Medical College(WuHu 241001)$$$$;MYOCARDIAL PROTECTIVE EFFECTS OF ASTRAGALUS PRETREATMENT ON ISCHEMIC REPERFUSION INJURY TO RAT HEARTS[J];Jiujiang Medical Journal;2002-01
7 CHEN Tu-gang, LUO Wei, CHENG Xiao-shu (Department of Cardiology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang 330006,China);Protective Effects of Ginsenosides on Cardiomyocytes Injured by Ischemia-Reperfusion[J];Acta Academiae Medicinae Jiangxi;2001-01
8 WT5BZ]SUN Ping long 1,SHANG Yun 2,WEI Xin guo 2, LI Xiao ning 2,ZHU Xiao mei 1, WEI Hong chang 1,YAN Shi yun 1 [WT5BX]1.?Shanghai University of Traditional Chinese Medicine 2.?Guang Ming Chinese Medicine Hospital, Nan;Influence of “Astragalus Heart Protecting Decoction” on Myocardial MDA and SOD Level and Myocardial Morphology in Rats with Experimental Myocardial Ischemia[J];ACTA UNIVERSITATIS TRADITIONIS MEDICALIS SINENSIS PHARMACOLOGIAEQUE SHANGHAI;2000-02
9 HAN Ya nan Directed by LI Ding Division of Chinese Medicine, Shanghai Bureau of Public Health;Influence of Herbal Drugs Applied on Acupoints on Myocardial Enzyme in Rats with Myocardial Ischemia[J];Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai;2001-03
10 ZHANG Ji-dong GAN Li-junQilu Hospital of Shandong University 250012;Effect of "Shumai Capsule" on Serum SOD and MDA in Patients with Angina Pectoris Following Coronary Heart Disease[J];Shanghai Journal of Traditional Chinese Medicine;2002-06
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