Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《JOURNAL OF PREVENTIVE MEDICINE OF CHINESE PEOPLE'S LIBERATION ARMY》 1999-02
Add to Favorite Get Latest Update

EFFECTS OF ACUTE HYPOBARIC HYPOXIA AND NON-HYPOXIA AT THE ALTIUDE OF 5 KM ON MICE IMMUNE SYSTEM

Gao Mei Wang Dianrui Xu Bin Zhang Xiaoxiu Jia Lei Chen Gang (Air Force Medical College, Jilin,132013)  
Objective:To explore the effects of acute hypobaric hypoxia and non-hypoxia at the altitude of 5 km on mice immune system and to analyse the main factor of them.Methods:Kunming mice were divided into three groups: hypobaric hypoxia group, hypobaric non-hypoxia group and control group. Experimental groups stayed at the altitude of 5 km in altitude chamber for 30 min, while the hypobaric non-hypoxia group was supplied with oxygen. Mice were killed then. The splenocyte proliferation level was assayed by 3 H-TdR incorporation; the activity of IL-1,IL-2 by mice thymocyte proliferation; the activity of IL-3 by mice myeloid cell proliferation.Results: The levels of T lymphocyte proliferation, IL-1,IL-2 in hypobaric hypoxia group were significantly suppressed when compared with those in control or hypobaric non-hypoxia group(P0.05);while the levels of B lymphocyte proliforation,IL-3 in experimental groups did not change significantiy when compared with those in control group(P0.05). Conclusion:Acute hypobaric hypoxia at 5 km can suppress cell mediated immunologic function of mice, and hypoxia is the main factor.
【Fund】: 空军医药卫生“九五”科研规划项目
【CateGory Index】: R852.11
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved