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Effects of Pellodendron on levels of DTH and Several Cellular Factors in DTH Mouse

Lü Yanning (吕燕宁), Qiu Quanying (邱全瑛)(Beijing University of Traditional Chinese Medicine, Beijing 100029)  
To research the immunosuppressive function of Pellodendron, we used DTH mouse model induced by DNFB to study the effects of Pellodendron on levels of DTH and several cellular factors. The results showed that Pellodendron can inhibit DTH in mouse induced by DNFB, also can decrease the levels of IFN γ, IL 1, IL 2 in mouse serum, inhibit its peritoneal macrophage producing IL 1 and TNF α, splenocytes producing IL 2. All suggest that Pellodendron has a function of suppressing the mouse DTH induced by DNFB, by means of inhibiting the production and secretion of cellular factors, such as IFN γ, IL 1, TNF α, IL 2 et al., to suppress immunologic pathologic lesion.
【Fund】: 非教育系统留学回国人员资助!B类课题
【CateGory Index】: R285
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