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《Journal of Beijing University of Traditional Chinese Medicine》 2004-05
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Research on the Inhibitory Effects of Hydroxysafflor Yellow A on the Rabbit Platelet Activation Induced by Platelet Activating Factor

Jin Ming,Gao Zichun, Wang Jifeng (The Department of Pharmacology, Beijing Institute of Cardiopulmonary Blood Vessel Diseases, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing, 100029)  
Objective To observe the inhibitory effects of Hydroxysafflor Yellow A (HSYA), which is an effective component of the dried flowers of Carthamus tinctorius used for activating blood and resolving blood stasis in TCM, on platelet activating factor (PAF)-induced rabbit platelet adhesion, 5-hydroxy tryptamine (5-HT) release, and increase in the level of free intraplatelet Ca 2+ of rabbit platelets. Methods Fluorospectrophotometry was used to detect the 5-HT released by the rabbit platelets activated by PAF, Fura-2 fluorospectrophotometry was used to observe the PAF-induced increase in the level of free intraplatelet Ca 2+ of rabbit platelets, and spectrophotometry was used to detect the PAF-induced enhancement of adhesion of rabbit platelets. Results The inhibitory effects of HSYA showed a marked dose-effect relationship when HSYA was used to treat PAF-induced enhancement of adhesion of rabbit platelets at doses of 479.6-1918.3 μmol/L, PAF-induced 5-HT release of rabbit platelets at doses of 280-1320 μmol/L, and PAF-induced increase in the level of free intraplatelet Ca 2+ of rabbit platelets at doses of 6.29-201.2 μmol/L. Conclusion HSYA can markedly inhibit PAF-induced enhancement of adhesion of rabbit platelets, PAF-induced 5-HT release of rabbit platelets, and PAF-induced increase in the level of free intraplatelet Ca 2+ of rabbit platelets.
【Key Words】: Hydroxysafflor Yellow A Platelet Activating Factor 5-Hydroxy Tryptamine Platelet Adhesion Free Intraplatelet Ca 2+
【Fund】: 国家自然科学基金资助项目 (No 3 9670 884)
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 10 Hits
1 LI Guo-li,CHEN Xie-yun,SUN Jing(TCM university of Hunan,Changsha,Hunan,410007 China);Curative effect of Ercong pill for sudden deafness of Qi-stagnancy and blood stasis[J];Journal of Traditional Chinese Medicine University of Hunan;2008-03
2 GAO Zi-zhen,XIA Xiao-yan,HUANG Qiu-yue,et al(Department of Pharmacochemistry and Natural Drugs,School of Pharmaceutical Sciences,Harbin Medical University,Harbin 150081,China);Study on ultrasonic wave aided extraction of safflor yellow from the flower of Carthamus tinctorius L.[J];Journal of Harbin Medical University;2008-06
3 Sarengaowa1,CHEN Hong-mei1,Quanshan2(1.Department of Clinical Mongolian Medicine Preparation,Affiliated Hospital of Inner Mongolia University for Nationalities,Tongliao 028000,China;2.Kulun Pharmaceutical Factory of Yili Resources Group,Kulun 028200,China);Summary of the Research on Chemical Compositions and Pharmacological Activities of Mongolian Drug Carthamus Tinctorius L.[J];Journal of Inner Mongolia University for Nationalities(Natural Sciences);2009-03
4 ZHANG Lin,SHEN Guo-shun,ZHANG Jing-nian,NIE Pie-he,ZHI Jian-ming(Department of Physiology,Basic Medical College,Shanghai Jiaotong University,Shanghai 200025,China);Vascular effect of hydroxyl-safflor yellow A and underlying mechanism[J];Journal of Shanghai Jiaotong University(Medical Science);2009-04
5 Gao Yan1,Chen Hang1,Jia Haihong1,et al.(The Affiliated Hospital of Hebei University,Baoding 071000,China);Effects of Safflow Yellow injection on TGF-β and ColⅠ in rats with renal interstitial fibrosis[J];Medical Research and Education;2009-03
6 JIN Xiaodong1 ZHANG Ming1Hunan Traditional Chinese Medical College,Zhuzhou 412012,China;Experimental Study on Treatment of Osteoarthritis with Honghua Injection[J];Chinese Journal of Traditional Medical Traumatology & Orthopedics;2009-03
7 JIN Xiaodong1 ZHANG Ming1Hunan Traditional Chinese Medical College,Zhuzhou 412012,China;Effect of Honghua Injection on Histopathology of Osteoarthritis Rabbits[J];Chinese Journal of Traditional Medical Traumatology & Orthopedics;2009-05
8 GAO Yan,YUAN Ai-jun,CHEN Hang,et al.The Affiliated Hospital of Hebei University,Baoding,Hebei 071000,China;Effect of safflow yellow injection on apoptosis of Renal tubular cells In rats with renal interstitial fibrosis[J];China Practical Medicine;2009-09
9 ZHANG Xin1,FANG Li2,NIU Xiao-li1,LI Song1(1.People's Hospital of Jilin Province,Changchun 130021,China;2.Traditional Chinese Medicine Hospital of Jilin Province,Changchun 130021,China);Effects of Safflower Yellow Injection on Nervous Function of Acute Cerebral Infarction[J];Journal of Beihua University(Natural Science);2009-06
10 Kang Lili,Gu Jian,He Bin,Shen Lianjun,Ji Wei.The Subei Pepole,s Hospital of Jiangsu Province,Institute of Hematology,Yangzhou,Jiangsu 225001,China;Alteration of the IL-18 Levels in the Different Stage of SLE and RA[J];Journal of Medical Research;2009-09
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Mo Shangwu; Chen Zhiheng; et al(Institute of Nuclear Science and Technology,Sichuan UnionUniversity, Chengdu);Influence of Safflower(Carthamus tinctorius)on Ca~(2+) Transmembrane Influx in Rat Aorta[J];Chinese Traditional and Herbal Drugs;1995-10
2 JIN Ming 1, GAO Zi-chun 2,LI Jin-rong 1,ZANG Bao-xia 1, WU Wei 1 (1. Department of Pharmacology,Beijing Institute of Heart,Lung,and Blood Vessel Diseases—Beijing Anzhen Hospital,Capital University of Medical Science,Beijing 100029,China;2. College of Chinese Materia Medica,Beijing University of Traditional Chinese Medicine,Beijing 100102,China);Preparation of safflor yellow and hydroxysafflor yellow A by macroporous resin column chromatography[J];Chinese Traditional and Herbal Drugs;2004-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 CUI Xin-ying,LIU Hui-min (Department of Pharmacology,College of Pharmacy,Beihua University,Jilin 132013,China);Effect of Xinjikang granule on hemodynamics in anesthetized chest-open dogs[J];Chinese Journal of Control of Endemic Diseases;2006-06
2 YANG Yuanyou LIU Ning QIU Mingfeng MO Shangwu WEI Jinxue JIN Jiannan (Institute of Nuclear Science and Technology, Key Laboratory of Radiation Physics and Technology of Education Ministry of China,Sichuan University, Chengdu 610064);Studies on functional fractions of fructus trichosanthes cortex by ~(45)Ca isotopic tracer technique[J];Nuclear Techniques;2002-05
3 ZHANG Hao-qin,ZHANG Xiao-fei,LIU Jin-dun,FANG Wen-ji(College of Chemical Engineering,Zhengzhou University ,Zhengzhou 450002,China);New Technique on Separation of Safflower Red and Safflower Yellow[J];Henan Chemical Industry;2006-02
4 Zhang Qian , Niu Xin, Yan Yan , et al.(Beijing University of Traditional Chinese Medicine, Beijing 100029);Research on the Mechanism of Hydroxysafflor Yellow A in Inhibiting Angiogenesis[J];Journal of Beijing University of Traditional Chinese Medicine;2004-03
5 Jin Ming,Piao Yongzhe,Wu Wei,et al (Beijing Institute of Cardiopulmonary Diseases and Angiopathy,Beijing, 100029);Remittent Effect of Safflor yellow on rat cardiac insufficiency induced by myocardial ischemia[J];Journal of Beijing University of Traditional Chinese Medicine;2005-02
6 ZHAO Wen-li 1,JIANG Qing-jiu 2,WU Ying 3 (1.Department of Pathology,Huizhou Municipal Center Hospital,Huizhou 516001,China;2.The First Affiliated Hospital,Jiamusi University,Jiamusi 154003,China;3.Taizhou Hospital,Taizhou 317000,China);Inhibitive effects of safflower on hepatofibrosis in rats[J];Heilongjiang Medicine and Pharmacy;2004-04
7 ZHAO Hong1,ZHANG Yu1,TIAN Yong-gang2,LIANG Yue1(1.The College of Chemistry and Pharmacy of Jiamusi University,Jiamusi 154007,China;2.Jiamusi Central Hospital,Jiamusi 154002,China);Extraction and separation of saponins from the Acer saccharum leaf[J];Heilongjiang Medicine and Pharmacy;2007-01
8 Wu Yan.Shao Yifu Hospital of Medical College,Zhejiang University.Hangzhou,310016;Study on Quality Criteria of Shujin Huoxue Capsules[J];Qingdao Medical Journal;2009-03
9 SUN Lei,FENG Lei,ZHAO Feng-sheng (School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China);Pilot experiment of reserpine purification[J];Chinese Journal of Biochemical Pharmaceutics;2007-04
10 ZHANG Ji-xiang1,BAI Xiao-jie1,ZHOU Qiu-xiang1,OU Lai-liang2,KONG De-ling2(1.Faculty of Chemistry and Material Science,Langfang Normal College,Langfang 065000,China;2.Key Laboratory of Bioactive Materials,Ministry of Education,Institute of Molecular Biology,Nankai University,Tianjin 300071,China);Separation and Purification of Safflor Yellow in Flor Carthami with Macroporous Absorption Resin[J];Lishizhen Medicine and Materia Medica Research;2009-08
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Xu Hongmei,Liu Qingyun,Dai Min,Peng Daiyin,Zi Xiaomei (Department of Pharmacy,Anhui College of TCM,Hefei 230038,China);THE EFFECT OF ANTI-THROMBUS ON TOTAL GLUCOSIDES OF CHISHAO[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-01
2 XU Tao,DAI Lin,JIANG An-hong,LONG Zi-jiang,ZHANG Min-hua(Anhui College of TCM,Anhui Hefei 230038,China);PATHOLOGICAL OBSERVATION ON EFFECT OF NANYANXIAO GRANULE ON EXPERIMENTAL PROSTATITIS IN RATS[J];Journal of Anhui Traditional Chinese Medical College;2001-01
3 GUO Gai-hui,FU Ren-jie (China-Japan Friendship Hospital,Beijing 100029,China);SYNDROME CHARACTERISTICS OF 170 MIDDLE AGED AND SENILE PATIENTS WITH ACUTE CEREBRAL INFARCTION[J];Journal of Anhui Traditional Chinese Medical College;2002-06
4 WU Hong-dong,SUN Zi-xue(The Center for Reproduction and Body Constitution of,Traditional Chinese Medicine,Beijing University of Traditional Chinese Medicine, Beijing 100029,China);Clinical Study on the Treatment of Chronic Prostatitis by Qianlieshu Pill and Awn Needle Therapy[J];Journal of Anhui Traditional Chinese Medical College;2006-05
5 WANG Ji, ZHANG Qian, XIE Hua, GU Li-gang, NIU Xu-yan, LIU Lin-tao (School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029,China);Effect of Hydroxy Safflor Yellow A on the proliferation of human umbilical vein endothelial cells with the stimulus of tumor cell conditioned medium[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-05
6 YI Cheng-la,CHEN An min,XU Wei guo,et al. (Department of Orthopedics,Tongji hospitol,Tongji Medical College,Huazhong University of Science and Techology,Wuhan 430030,China);Study of correlation between Caspase-3 expression and neural cell apoptosis after spinal cord injury in rats[J];Journal of Traumatic Surgery;2004-03
7 LI Shu-ping,MENG Shuang-yan,LI Rui.The Department of Laboratory Medicine,Huaihua Medical College,Huaihua,Hunan 418000,China;The relationship between four cytokines levels in serum and in prostatic fluid and chronic abacterial prostatitis[J];Journal of Chinese Physician;2005-11
8 Zeng Huawu, Li Yiming, He Xiang, Jiang Yuanying, Jiang Shanhao, Zhu Dayuan (Department of Natural Medicinal Chemistry, College of Pharmacy, Second Military Medical University, Shanghai, 200433);Antiinflammatory and antioxidant effects of the extracts from Scrophularia ningpoensis Hemsl.[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1999-09
9 GUO Mei-Li, JIANG Wei, ZHANG Zhi-Zhen, ZHANG Ge, MAO Ji-Fang, YIN Ming, SU Zhong-Wu ( Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433,China; Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences; Department of Pharmacology, School of Pharmacy);Randomly amplified polymorphic DNA technique in molecular identification of germplasms of Carthamus tinctorius L.[J];Academic Journal of Second Military Medical University;2003-10
10 ;Study on chemical constituents of Flos Carthami(Ⅱ)[J];Academic Journal of Second Military Medical University;2005-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 GUAN Hui et al (College of Animal Science & Technology,Shihezi University,Shihezi,Xinjiang 832003);Effect of Yizhikang Powder on Haemorheological Indices on Dairy Cattle with Retained Placenta[J];Journal of Anhui Agricultural Sciences;2009-09
2 TAN Yong et al(Key Laboratory for Special Plant Drug Resources of Xinjiang,Pharmaceutical College,Shihezi University,Shihezi,Xinjiang 832002);Analysis on the Contents of Microelements and Heavy Metal Elements and Hydroxy Safflower Yellow A in Carthamus tinctorius from Different Producing Areas[J];Journal of Anhui Agricultural Sciences;2009-12
3 LIU Yan1,FU Yue-Xian1,TANG Kai-Yong2,ZHU Jin2,QIU Lin1,TIAN Xiao-Fei1,GAN Li-Qiang1,XIAO Jun11Department of Burns and Plastic Surgery,2Department of Pathology,Children's Hospital,Chongqing Medical University,Chongqing 400014,China;Effect of carthamus tinctorius on connective tissue growth factor expression in hypertrophic scar of rabbit's ears[J];Journal of the Fourth Military Medical University;2009-18
4 YANG Hui.Department of Pharmacy,Central Hospital of China Petroleum,Hebei,Langfang 065000;Effect of Kuntongning capsule on experimental dysmenorrhea and its analgesic mechanism[J];Hebei Journal of Traditional Chinese Medicine;2009-01
5 LI Xuemei,SUN Xiaojie.Department of Endocrine,Rizhao City Hospital of TCM,Shandong,Rizhao 276800;Influence of Buyanghuanwu decoction on blood sugar,hemorheology and insulin resistance of type 2 diabetes[J];Hebei Journal of Traditional Chinese Medicine;2009-04
6 SUN Guo-rong,XIAO Si-wang(TCM University of Hunan,Changsha,Hunan 410007,China);Effect of Taohong Siwu decoction on expression of serum IL-2,IL-6 and TNF-α after knee joint replacement[J];Journal of Traditional Chinese Medicine University of Hunan;2008-03
7 Chen Hongci(Hubei Hospital of Traditional Chinese Medicine,Wuhan,Hubei,430061);Influence of Danhong Injection on Hemorheology of Senile Patients with Chronic Obstructive Pulmonary Disease (COPD)[J];Henan Traditional Chinese Medicine;2007-09
8 Wang Yan,Zhu Xiaojing,Li Ying,et al.Department of Pathology,Jiangsu Provincial Insititute of Traditional Chinese Medicine,Nanjing,210028;Change of proliferating and apoptosis of keratinocytes in condyloma acuminatum before and after the treatment with Qu-You lotion[J];China Journal of Leprosy and Skin Diseases;2008-11
9 WU Xiang-Feng①,LIU Jun,SHEN Juan,WEI Li-Ping(①Institute of Drug and Instrument Control of PLA,Beijing 100071 China);Study on Quality of Liu Rui Capsules[J];Pharmaceutical Journal of Chinese People's Liberation Army;2009-05
10 Jia Feifei1,Chai Qiuyan2,Jia Jun1,Zhang Liwei1(1.Institute of Molecular Science of Shanxi University,Taiyuan Shanxi 030006;2.Shanxi Institute of Medicine and Life Science,Taiyuan Shanxi 030006);Study on the Antithrombotic Effect of Safflower Yellow B[J];Journal of Shanxi College of Traditional Chinese Medicine;2009-03
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Wang Bingzhang, Yang Minggang, Pang Lei and Yu Zhanjiu(Laboratory of Pathophysiology, Hebei Academy of Medical Sciences, Shijiazhuang);EFFECT OF HONG-HUA (FLOS CARTHAMI) ON THE EXTENT OF MYOCARDIAL ISCHEMIA IN THE DIFFERENT INFARCT ZONES FOLLOWING CORONARY OCCLUSION IN THE DOG[J];Acta Pharmaceutica Sinica;1979-08
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