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《Journal of Beijing University of Traditional Chinese Medicine》 2004-05
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Research on the Inhibitory Effects of Hydroxysafflor Yellow A on the Rabbit Platelet Activation Induced by Platelet Activating Factor

Jin Ming,Gao Zichun, Wang Jifeng (The Department of Pharmacology, Beijing Institute of Cardiopulmonary Blood Vessel Diseases, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing, 100029)  
Objective To observe the inhibitory effects of Hydroxysafflor Yellow A (HSYA), which is an effective component of the dried flowers of Carthamus tinctorius used for activating blood and resolving blood stasis in TCM, on platelet activating factor (PAF)-induced rabbit platelet adhesion, 5-hydroxy tryptamine (5-HT) release, and increase in the level of free intraplatelet Ca 2+ of rabbit platelets. Methods Fluorospectrophotometry was used to detect the 5-HT released by the rabbit platelets activated by PAF, Fura-2 fluorospectrophotometry was used to observe the PAF-induced increase in the level of free intraplatelet Ca 2+ of rabbit platelets, and spectrophotometry was used to detect the PAF-induced enhancement of adhesion of rabbit platelets. Results The inhibitory effects of HSYA showed a marked dose-effect relationship when HSYA was used to treat PAF-induced enhancement of adhesion of rabbit platelets at doses of 479.6-1918.3 μmol/L, PAF-induced 5-HT release of rabbit platelets at doses of 280-1320 μmol/L, and PAF-induced increase in the level of free intraplatelet Ca 2+ of rabbit platelets at doses of 6.29-201.2 μmol/L. Conclusion HSYA can markedly inhibit PAF-induced enhancement of adhesion of rabbit platelets, PAF-induced 5-HT release of rabbit platelets, and PAF-induced increase in the level of free intraplatelet Ca 2+ of rabbit platelets.
【Key Words】: Hydroxysafflor Yellow A Platelet Activating Factor 5-Hydroxy Tryptamine Platelet Adhesion Free Intraplatelet Ca 2+
【Fund】: 国家自然科学基金资助项目 (No 3 9670 884)
【CateGory Index】: R285.5
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