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《Journal of Beijing University of Traditional Chinese Medicine》 2007-05
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Preparation and dissolution properties of solid dispersions of puerarin with polyethylene glycol 6000

WANG Zhan, HAN Li-wei, REN Tian-chi (School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100029)  
Objective To prepare solid dispersions of puerarin with polyethylene glycol 6000 (PEG6000) to improve its dissolution and solubility. Methods The solid dispersions of puerarin were prepared by the fusion method with PEG6000 as the carrier. Evaluation of the properties of the dispersions was performed using dissolution studies, ultraviolet spectroscopy (UV), infrared spectroscopy (IR) and differential scanning calorimetery (DSC). Results The rate of dissolution and the solubility of puerarin in the solid dispersions prepared by the optimized preparing process were incresced 3 times and 17 times respectively as compared with crude puerarin. The data of UV, IR and DSC showed the absence of well-defined drugpolymer interactions. Conclusion The dissolution and solubility of puerarin could be improved significantly in solid dispersions with PEG6000.
【Fund】: 国家自然科学基金(No.30400601)
【CateGory Index】: R283.1
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