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《Journal of Beijing University of Traditional Chinese Medicine》 2007-11
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Effect of Shumai Capsules on earlier period atherosclerosis of extremity in rabbits and its mechanism

DONG Jian-xun1,HAO Yu2,SUN Dan2,et al.(1 Beijine Hospital of Chinese Medicine,Capital Medical University,Beijing 100010;2 Beijing University of Chinese Medicine)  
Objective To investigate the effect of Shumai Capsules(SMC) on the earlier period atherosclerosis obliterans(ASO) in rabbits and to explore the mechanism of it.Methods Eighteen male Japanese albino rabbits were randomly divided into three groups,the control group,the model group and the SMC treatment group.The right iliac arteries of the later two groups were stimulated by electric current generated by a thrombosis inducer,while the ones in the control group were treated with sham operation.From the day after the operation,the model group and the SMC treatment group were fed with high-fat diet(with 3% lard and 1% cholesterol),the SMC group was given SMC by intragastric administration,and the control group was fed with the standardized rabbit food for all the period.On the 2nd and 15th day after the operation,the model group and the SMC treatment group were respectively injected with 10% bovine serum albumin 250 mg/kg.The whole experiment lasted for 60 days.When the experiment was over,the levels of serum total cholesterol(TC),triglyeride(TG),high density lipoprotein-cholesterol(HDL-C) and low density lipoprotein-cholesterol(LDL-C) were detected.The iliac arteries were harvested for the HE staining to observe the patho-appearance of the blood vessels and the wall of thoracic aortae was stained with magdala red Ⅲ.Results ①Under the light microscope the iliac arteries in the control group showed integrated and continuation,and endothelial cells were lined up in order.The intima was thin.The model group showed a stegnosed lumens and a obviously thick intima filled with lots of foam cells full of fat.Compared with the model group,the theca interna from the SMC group was thinner,and the number of foam cell was fewer.②In the control group,thoracic aorta intima was smooth,and in the model group thoracic aorta intima was rough with atheromatous plaques.In the SMC treatment group,atheromatous plaques were decreased significantly when compared with those in the model group.③Compared with the control group,the levels of serum TC,TG,HDL-C and LDL-C were significantly increased in the model group(P0.01),while those results turned out a lower tendency in the SMC treatment group than in the model group.Significant differences only existed in LDL-C(P0.05)and TG(P0.01).Conclusion SMC can relieve ASO by way of regulating lipid metabolism.
【Fund】: 北京市中医药科技发展基金项目(No.JJ2005-13)
【CateGory Index】: R285
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