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《Journal of Beijing University of Traditional Chinese Medicine》 2009-01
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Effect of Jianpibushenjiedu Formula on mice Lewis lung carcinoma and cell cycle of A549 lung carcinoma cells

CAO Yong,MENG Jin-cheng,XIA Qing-hua,MENG Hua,CHEN Lu,XU Lin-li,LI Liang(Department of TCM,Medical College of Jinan University,Guangdong 510632)  
Objective To study the effect of Jianpibushenjiedu Formula(JPBSJDF) on lung carcinoma and its mechanism.Methods The mice-transplanted Lewis lung cancer were randomly divided into model control group; JPBSJDF high dosage group,medium dosage group and low dosage group;cisplatin(DDP)group;JPBSJDF high dosage ,medium and low dosage combined respectively with DDP group. The drug-serum with JPBSJDF high and low dosage group,and model control group from tumor-bearing animals were prepared. The effect of JPBSJDF on antitumor of mice Lewis lung carcinoma and its drug-serum on cell cycle of human lung carcinoma A549 cells were observed respectively.Results JPBSJDF had certain inhibitory effect on mice Lewis lung carcinoma,and enhanced inhibitary and lethal effect of DDP to lung carcinoma cells. JPBSJDF drug-serum could significantly block the A549 cells at the G0-G1 phase,which decreased cell ratio in the S phase (P0.01).Conclusion JPBSJDF has effect of antitumor and synergy. Tumor cell cycle inhibiting probably contributes to this effect.
【Fund】: 广东省科技计划项目(No.73062);; 广州市科技计划项目(No.2007Z3-E5091);; 广东省中医药管理局项目(No.2040030)
【CateGory Index】: R285.5
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