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《Journal of Beijing University of Traditional Chinese Medicine》 2009-07
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Influence of Biejiajian Pills on cell proliferation in rats with renal interstitial fibrosis

HAN Lin1,QIN Jian-guo2,CHEN Zhi-qiang3,XU Qing-you3,LI Peng-tao4(1 School of Fundamental Medicine,Beijing University of Chinese Medicine,Beijing 100029;2 Dongfang Hospital,Beijing University of Chinese Medicine;3 Institute of Integration of Chinese and Western Medicine,Hebei Medical University;4 Dongzhimen Hospital,Beijing University of Chinese Medicine)  
Objective To observe the influence of Biejiajian Pills on cell proliferation in rats with renal interstitial fibrosis,and discuss the mechanism of Biejiajian Pills for antagonizing renal interstitial fibrosis.Method The model of renal obstruction was established by unilateral ureteral obstruction(UUO) in rats,and then the rats were randomly divided into Biejiajian Pills group,valsartan group and model group.The sham-operation group was established in addition.The protein and gene expressions of renal proliferating cell nuclear antigen(PCNA) were observed,and the proliferation,apoptosis and cell cycle of interstitial and tubular cells were detected.Result In the model group,Biejiajian Pills group and valsartan group the protein and mRNA expressions of PCNA,the positive cell rate and apoptosis rate of interstitial and tubular cells were higher significantly than those in the sham-operation group(P0.05,P0.01).In Biejiajian Pills group and valsartan group the protein and mRNA expressions of PCNA were lower than those in the model group(P0.05,P0.01).The ratio of apoptosis to proliferation was lower significantly in the model group than that in the sham-operation group(P0.05),but it was higher significantly in Biejiajian Pills group and valsartan group than that in the model group(P0.05).Compared with the sham-operation group,in the model group the proportion of S-phase fractions(SPF) increased significantly(P0.01),and the proportion of G0/G1-phase fractions(GPF) decreased significantly(P0.01).Compared with the model group,in Biejiajian Pills group and valsartan group the proportion of SPF decreased significantly(P0.05),that of GPF increased significantly(P0.01),and that of G2/M-phase fractions had no obvious change.Conclusion Biejiajian Pills can down-regulate the protein and mRNA expression of PCNA in renal interstitial cells,promote apoptosis and inhibit proliferation of interstitial cells,prevent interstitial cells going into S-phase from G0/G1-phase,and protect the kidney in rats with renal interstitial fibrosis.
【Fund】: 教育部博士点新教师基金资助项目(No.200800261025)
【CateGory Index】: R285.5
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