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《Journal of Beijing University of Traditional Chinese Medicine(Clinical Medicine)》 2008-04
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Influence of Buyanghuanwu Decoction on expression changes of cerebral TNF-α,ICAM-1 and VCAM-1 in aged rats with cerebral ischemia-reperfusion lesion

GAO Jian-feng1,WANG Xiao-hui2,LIU Ke3,LU Min1 (1 Department of Physiology,Henan College of Chinese Medicine,Henan 450008; 2 Department of Pathology,Jinshui Hospital,Zhengzhou City,Henan Province; 3 Department of Encephalopathy,First Affiliated Hospital of Henan College of Chinese Medicine)  
Objective To find out the protective mechanism of Buyanghuanwu Decoction for antagonizing senile cerebral ischemia-reperfusion lesion on the base of expression changes of tumor necrosis factor-α (TNF-α),intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Method The animal model of cerebral ischemia was established by using middle cerebral artery occlusion (MCAO). The nervous symptom scores,brain water content and pathological changes,and the expressions of TNF-α,ICAM-1,VCAM-1 and ICAM-1mRNA were observed after ischemia for 3 hours,and ischemia-reperfusion lesion for 1,3,6 and 12 days respectively. Result In the model group the brain water content (ischemia-reperfusion for 1,3 and 6 days),nervous symptom scores (at all time points),expressions of TNF-α and VCAM-1 (ischemia for 3 hours,ischemia-reperfusion for 1,3 and 6 days),ICAM-1 (ischemia for 3 hours,ischemia-reperfusion for 1,3 and 6 days) and mRNA (at all time points) were all higher than those in the sham-operation group. In the Buyanghuanwu Decoction group the nervous symptom scores and brain water content (ischemia-reperfusion for 3,6 and 12 days),the expressions of TNF-α,VCAM-1,ICAM-1 and mRNA (ischemia for 3 hours,ischemia-reperfusion for 1 and 3 days) were all lower than those in the model group. In the Buyanghuanwu Decoction group the nervous symptom scores (ischemia-reperfusion for 6 and 12 days),the expressions of TNF-α (ischemia-reperfusion for 1 day),ICAM-1 (ischemia-reperfusion for 1 day) and mRNA (ischemia-reperfusion for 1 and 3 days) were all lower than those in the nimodipine group. Conclusion The mechanism of Buyanghuanwu Decoction for antagonizing senile cerebral ischemia-reperfusion lesion may be related to its inhibitory effect on the expressions of TNF-α,ICAM-1 and VCAM-1.
【Fund】: 国家自然科学基金资助项目(No.30371812)
【CateGory Index】: R285.5
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