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《Journal of Beijing University of Traditional Chinese Medicine(Clinical Medicine)》 2010-02
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Influences of Chaihushugan Powder on behaviors and serum levels of ACTH and CORT in rat model of liver-depression syndrome

DU Ya-wei1, WANG Yu-lai1, YIN Ling2, ZHAO Xiu-mei2, YAO Zhuo-ting1, LI Dan2 (1 Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078; 2 Neurological Information Center, 301 Hospital of Chinese PLA)  
Objective To study the influences of Chaihushugan Powder on the behaviors and serum levels of adrenocorticotropic hormone (ACTH) and cortisol (CORT) in rat model of liver-depression syndrome. Methods All rats were divided into the blank control group, liver-depression model group and Chaihushugan Powder group. The rat model of liver-qi depression syndrome was established by using die bandage combining with independent feeding. The changes of ethological indexes of open-field behaviors in rats were observed, and the levels of ACTH and CORT were detected by using radioimmunoassay. Results Chaihushugan Powder improved the horizontal and vertical movements, decreased the stopping time in middle position, and reduced the levels of ACTH and CORT in rat model of liver-qi depression syndrome. Conclusion Chaihushugan Powder had an antagonized effect on liver depression, and the mechanism may be related to that it can regulate the levels of ACTH and CORT.
【CateGory Index】: R256.49
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