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《Journal of Beijing University of Traditional Chinese Medicine(Clinical Medicine)》 2010-06
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Influences of Chaihushugan Powder on ethology and levels of GAS and MLT in rat model of liver depression syndrome

DU Ya-wei1,WANG Yu-lai2,YIN Ling3,ZHAO Xiu-mei3,YAO Zhuo-ting4,QIN Shao-lin2(1 Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700;2 Dongfang Hospital,Beijing University of Chinese Medicine;3 Center of Neurological Information,General Hospital of Chinese PLA;4 People's Health Publishing House)  
Objective To study the influences of Chaihushugan Powder on the ethological changes and levels of serum gastrin(GAS) and plasma motilin(MTL) in rat model of liver depression syndrome.Methods All rats were divided into the blank control group,the model group of liver depression syndrome and the Chaihushugan Powder group.The method combining die bound and lonely feeding was used to establish the rat model of liver depression syndrome.The changes of ethological indexes of immobility time in forced swimming test were observed after the administration of Chaihushugan Powder,and the levels of serum GAS and plasma MLT were detected by using radioimmunoassay.Results Chaihushugan Powder reduced the immobility time in forced swimming test,and increased the levels of serum GAS and plasma MTL in the rat model of liver depression syndrome.Conclusion Chaihushugan Powder has the effect of antagonizing liver depression and the mechanism may be related to that it can regulate the levels of serum GAS and plasma MTL.
【CateGory Index】: R256.49
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