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《Journal of Jinzhou Medical College》 2004-04
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PYM-induced Apoptosis in Human Larynx Squamous Hep-2 Cells

TAI Jun, WANG Xue-feng, LI Bing,FENG Shi-liang,LI Yan-qin (Department of ORL-HNS, the First Affiliated Hospital of Jinzhou Medical College,Jinzhou 121000 China)  
Objective To demonstrate whether Pingyangmycin can induce the apoptosis in human larynx squamous cell line (Hep-2). Methods Hep-2 cells were exposed to different concentrations of PYM and evaluated by TUNEL and Electron microscope. Flow cytometric DNA analysis was used to analyze the peak appeared in DNA frequency distribution histograms.Results Hep-2 cells in the presence of low concentrations of PYM (1μg/ml, 10μg/ml) showed no significant apoptosis. In contrast, cells in the presence of high concentration (100μg /ml, 1000μg /ml) exhibited the morphological and biochemical changes associated with apoptosis.To some extent,the effect was dose-time dependent.Conclusions The results of study demonstrate that Pingyangmycin can induce Hep-2 cells apoptosis,which has the clinical significance of the chemotherapy of human larynx squamous cancer cells.
【CateGory Index】: R739.65
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