Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Jinzhou Medical College》 2004-04
Add to Favorite Get Latest Update

PYM-induced Apoptosis in Human Larynx Squamous Hep-2 Cells

TAI Jun, WANG Xue-feng, LI Bing,FENG Shi-liang,LI Yan-qin (Department of ORL-HNS, the First Affiliated Hospital of Jinzhou Medical College,Jinzhou 121000 China)  
Objective To demonstrate whether Pingyangmycin can induce the apoptosis in human larynx squamous cell line (Hep-2). Methods Hep-2 cells were exposed to different concentrations of PYM and evaluated by TUNEL and Electron microscope. Flow cytometric DNA analysis was used to analyze the peak appeared in DNA frequency distribution histograms.Results Hep-2 cells in the presence of low concentrations of PYM (1μg/ml, 10μg/ml) showed no significant apoptosis. In contrast, cells in the presence of high concentration (100μg /ml, 1000μg /ml) exhibited the morphological and biochemical changes associated with apoptosis.To some extent,the effect was dose-time dependent.Conclusions The results of study demonstrate that Pingyangmycin can induce Hep-2 cells apoptosis,which has the clinical significance of the chemotherapy of human larynx squamous cancer cells.
【CateGory Index】: R739.65
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 PENG Xinz hao 1, SHEN Zhong ying 2, LI Miao juan 2, et al. 1.Central Laboratory , First Military Medical University,Guangzhou 510515, P.R.China 2.Department of Pathology,Shantou University Medical College,Shantou 515031,P.R.China;Pingyangmycin induced apoptosis in human esophageal carcinoma cells EC8712[J];CHINESE JOURNAL OF CANCER;1999-06
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Ll Xianxi;HE Haiying; WANG Bo; ZHANG Jiaping; LIANG Kang;CHANG Changying(Department of Biochemistry and Molecular Biology,Beijing Medical University 100083);STUDY OF DNA DAMAGE AND REPAIR IN RAT'S CATARACT INDUCED BY PINGYANGMYCIN[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1996-03
2 WangChaofu;Liang Yingrui(Dept of Pathol,Bangpu Medical College,233002,Medical College of Shantou University,Guangdong 515031);In Situ end labeling detectin for apoptosis in hepatocellular carcinoma[J];CHINESE JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOG;1996-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved