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《Acta Entomologica Sinica》 2008-06
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Molecular mechanism of action of novel diamide insecticides on ryanodine receptor

TANG Zhen-Hua~1, TAO Li-Ming~2 (1. Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China; 2. Shanghai Pesticide Research Institute, Shanghai 200032, China)  
Diamide insecticide flubendiamide and chlorantraniliprole, with ryanodine receptors (RyRs) as targets, were recently discovered. Here we reviewed the structure and function of RyR, regulation of intracellular calcium homeostasis by voltage-gated calcium channel and RyR/calcium release channel and molecular mechanisms of action of diamide insecticides on RyRs. Diamide insecticides stabilize insect RyR channels to open state, evoking massive calcium release from intracellular stores, and then disrupt the calcium homeostasis, and possess distinct pharmacological characteristics, which are mediated by a binding site different from that of ryanodine. The action of this class of insecticides is highly specific to insect RyRs and results in selective toxicity. Diamide insecticides have a unique chemical structure and a novel mode of action and show excellent efficacy, a broad insecticidal spectrum against lepidopterous insect pests, excellent safety against various beneficial arthropods and natural enemies, and no cross-resistance to existing insecticides. They will be very suitable for insecticide resistance management and IPM programs.
【Fund】: 国家重点基础研究发展规划(“973”计划)(2003CB114403)
【CateGory Index】: S482.3
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