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《Acta Entomologica Sinica》 2014-04
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Molecular mechanisms of insecticide resistance mediated by cytochrome P450s in insects

QIU Xing-Hui;State Key Laboratory of Integrated Management of Pest Insects and Rodents,Institute of Zoology,Chinese Academy of Sciences;  
Although cytochrome P450s have been well known to play crucial roles in insecticide resistance in insects, the mechanisms of P450-based metabolic resistance have not been fully characterized at the molecular level. Thanks to the development of genomics and biochemical techniques,rapid advances in the studies on the mechanisms of P450-mediated insecticide resistance have been achieved in recent years. This review attempts to summarize the current understandings in this field. P450-mediated resistance is a very common mechanism for almost all types of insecticides,and a single P450 enzyme may confer cross-resistance to different classes of pesticides. Variable genetic basis of resistance has been documented between populations resistant to the same insecticide due to multiple P450 options for evolving resistance. P450-mediated resistance may be due to either increased enzyme production( via enhanced transcription and /or gene duplication and amplification),or a change in structural gene itself that may alter the catalytic properties of the enzyme( caused by point mutations),or gene recombination of two closely linked genes that creates a chimeric enzyme with a novel ability. Constitutive transcriptional overexpression of resistance-associated P450 can be caused by cis- or /and trans-acting factors that have not been well understood. These findings suggest that mechanisms underlying P450-mediated insecticide resistance are diverse and complicated, and resistance monitoring and management should be customized for specific populations in a dynamic context.
【Fund】: 国家自然科学基金项目(31172160);; 国家重点基础发展研究规划(“973”计划)项目(2012CB114103)
【CateGory Index】: Q966
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