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Effect of Gypenosides on Formation of Atherosclerotic Plaque of Aorta in Hypercholesterolemic Rabbits

HUANG Hong-Lin;YIN Wei-Dong;LIAO Duan-Fang;CHEN Jian-Xiong;TANG Xiao-Qing;LI Bo-Ping;CAO Jian-Guo and YU Lin (Division of Cardiopulmonary Pharmacology,Institute of Cardiovascular Diseases,Hengyang Medical College,Hengyang 421001,Chinas)  
Aim To investigate the effects and mechanisms of Gypenosides on the atherosclerotic plaque formation in rabbit with hypercholesterolemia.Methods 23 male New Zealand white rabbits were assigned to four groups:5 rabbits in control group were fed with a normal diet;8 rabbits in hyperc-holesterolemic group were fed with 1% cholesterol diet for 9 weeks;In gypenosides and vitamine E (Vit E)treat groups,5 weeks after fed with 1% cholesterol di-et the animals were fed with 1% cholesterol diet con-taining gypenosides or Vit E for another 4 Weeks.Sudan IV stain was used to show the relative area ofatherosclerotic plaque.Lipid peroxides of aorta were estimated by the thiobarbituric acid method.Nitrite,the matabolic product of nitric oxide,was determined according to a modified Griess' method.The Ca2+.K+ and Na+ content of aorta were measured in means of atom absorption.Results Gypenosides treatment (120 mg/d,4weeks)inhibited formation of atherosclerotic plaque as shown by 37% reduction of plaque areas comparing to 1% cholesterol treatment along.Gypenosides also decreased lipoperoxidation of aorta by 33%.In addi-tion,gypenosides protected nitric oxide release of aorta against hypercholesterolemia damage and reduced Ca2+content of aorta by 50%.However,both hyperc-holesterolemia and gypenosides had no influence on K+and Na+ content of aorta.Vit E showed the same ef-fect as gypenosides did.Conclusion Gypenosides atlenuates the formatiom of atherosclerotic plague and lipoperoxidation of aorta induced by hypercholesterolemin in rabbit.The mecha-nisms of antiatherogenic effects of gypenosides might include its protection on nitric oxide and its inhibition on calcium overload.
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