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《CHINESE JOURNAL OF ARTERIOSC LEROSIS》 1998-04
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Effect of Gypenosides on Formation of Atherosclerotic Plaque of Aorta in Hypercholesterolemic Rabbits

HUANG Hong-Lin;YIN Wei-Dong;LIAO Duan-Fang;CHEN Jian-Xiong;TANG Xiao-Qing;LI Bo-Ping;CAO Jian-Guo and YU Lin (Division of Cardiopulmonary Pharmacology,Institute of Cardiovascular Diseases,Hengyang Medical College,Hengyang 421001,Chinas)  
Aim To investigate the effects and mechanisms of Gypenosides on the atherosclerotic plaque formation in rabbit with hypercholesterolemia.Methods 23 male New Zealand white rabbits were assigned to four groups:5 rabbits in control group were fed with a normal diet;8 rabbits in hyperc-holesterolemic group were fed with 1% cholesterol diet for 9 weeks;In gypenosides and vitamine E (Vit E)treat groups,5 weeks after fed with 1% cholesterol di-et the animals were fed with 1% cholesterol diet con-taining gypenosides or Vit E for another 4 Weeks.Sudan IV stain was used to show the relative area ofatherosclerotic plaque.Lipid peroxides of aorta were estimated by the thiobarbituric acid method.Nitrite,the matabolic product of nitric oxide,was determined according to a modified Griess' method.The Ca2+.K+ and Na+ content of aorta were measured in means of atom absorption.Results Gypenosides treatment (120 mg/d,4weeks)inhibited formation of atherosclerotic plaque as shown by 37% reduction of plaque areas comparing to 1% cholesterol treatment along.Gypenosides also decreased lipoperoxidation of aorta by 33%.In addi-tion,gypenosides protected nitric oxide release of aorta against hypercholesterolemia damage and reduced Ca2+content of aorta by 50%.However,both hyperc-holesterolemia and gypenosides had no influence on K+and Na+ content of aorta.Vit E showed the same ef-fect as gypenosides did.Conclusion Gypenosides atlenuates the formatiom of atherosclerotic plague and lipoperoxidation of aorta induced by hypercholesterolemin in rabbit.The mecha-nisms of antiatherogenic effects of gypenosides might include its protection on nitric oxide and its inhibition on calcium overload.
【Fund】: 湖南省教委资助!1191206
【CateGory Index】: R965
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【References】
Chinese Journal Full-text Database 5 Hits
1 TANG Xiao-qing,ZHU Bing-yang,CHEN Jian-xiong,et al (Institute of Pharmacy & Pharmacology,Nanhua University,Hengyang,Hunan 421001,China) [WT5HZ];Protective Effect of Gypenosides on Ischemic Brain Damage Induced by Photochemistry[J];Journal of Hengyang Medical College;2001-02
2 HUANG Hong Lin, CHEN Lin Xi, ZHU Bin Yang, YU Lin, LIAO Duan Fang (Division of Cardiopulmonary Pharmacology,Hengyang Medical College,Hengyang 421001);Effects of gypenosides on c sis expression of bovine aortic endothelial cells and proliferation of vascular smooth muscle cells induced by lipopolysaccharide and active oxygen species[J];CHINESE PHARMACOLOGICAL BULLETIN;1999-04
3 YANG Yun Bo, LIAO Duan Fang 1, XIE Zhi Zhong 1, HUANG Hong Lin 1 (Dept of Pharmacology, Institute of Pharmacy,Traditional Chinese Medical College,Changsha 410007);Probucol prevention against restenosis by regulating functional vascular remodeling after percutaneous transluminal angioplasty in rabbits[J];Chinese Pharmacological Bulletin;2003-04
4 YANG Yun-bo, LIAO Duan-fang, ZHU Bing-yang (Institute of Pharmacy and Pharmacology, Nanhua University, Hengyang 421001, China);Probucol prevents restenosis by regulating vascular remodeling after percutaneous transluminal angioplasty in rabbits[J];Chinese Journal of Pathophysiology;2003-09
5 Wu Baojie, Ding Hua (Department of Pharmacology, Preclinical Medical College, Shandong Medical University, Jinan 250012);PROSPECT FOR DEVELOPMENT OF ANTIATHEROSCLEROTIC OF BIOLOGICAL ORIGIN[J];CHINESE NEW DRUGS JOURNAL;2000-05
【Citations】
Chinese Journal Full-text Database 7 Hits
1 Lei Jianhua;et al(Department of Physiology Hengyang healthy academy,Hengyang,Hunan);Preventive Effect of Gypenoside Against Endotoxic Shock-Induced DIC in rabbit[J];JOURNAL OF HENGYANG MEDICAL COLLEGE;1994-02
2 JIAO Hong-Li;;LIU Yi-Lin;; WAN La-Xiang;; HU Long-Mei;;YANG He-Ping and YANG Yong-Zong(Molecular Biology Center,Hengyang Medical College,Hengyang 421001, Guangdong Province Yuebei Hospital,Shaoguan 512026, Nanyue Pharmaceutical Factory,Hengyang 421001. C;Effects of L-arginine on Atherosclerotic Plaque Area of Aortae and Coronary Arteries in Rabbit with Hypercholesterolemia[J];CHINESE JOURNAL OF ARTERIOSC LEROSIS;1997-03
3 LIAO DuanFang;YIN Wei-Dong;CHEN JianXiong;TEN Hua;TAN Xiao-Qing;LI Bo-Ping and YU Lin (Department of Cardiopulmonary Pharmacology,Institute of Cardiovascular Disease,Hengyang Medical College,Hengyang 421001,China);Effect of Gypenosides on Nitric Oxide and Lipid Peroxidation in Blood-serum of Diet-induced Atherosclerotic Rabbit[J];CHINESE JOURNAL OF ARTERIOSC LEROSIS;1994-04
4 Li Lin1, Xing Shantian, Zhou Jinhuang ( Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850);PROTECTIVE EFFECTS OF GYPENOSIDES ON RAT HEPATIC LIPID PEROXIDATION AND MEMBRANE FLUIDITY DAMAGE: IN VITRO STUDIES[J];Chinese Pharmacological Bulletin;1991-05
5 IU Li-Bo,HU Bi,LIAO Duan-Fang1 (Dept of Physiology; 1Dept of Pharmacology, Hengyang Medical College,Hunan 421001);Protective effect of gypenosides on free radical damage of isolated guinea pig papillary muscles[J];Chinese Pharmacological Bulletin;1993-04
6 XIAO Guan-Lian,LIAO Duan-Fang; CHEN Jian-Xiong; YU Lin (Dept.of pharmacology, Hengyang Medical College, Hunan 421001);Protective effect of gypenosides on OFR-induced damage of relaxing capacity of rabbit thoracic aortae in vitro[J];CHINESE PHARMACOLOGICAL BULLETIN;1994-02
7 ZHAO Ying, HU DaYi(Lab of Heart Center, Beijing Red Cross Chao Yang HospitalAffiliate of Capital University of Medicine, Beijing 100020);Effect of GP on action potentials,Lcalcium channel currents, sodium channel currents and potassium channel currents in isolated single ventricular myocyte of guinea pigs[J];CHINESE PHARMACOLOGICAL BULLETIN;1998-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Le-zhen XU Jing-ya YANG Jun LU Li-ping ZHANG Yong-zhong(Institute of Integration of Traditional Chinese and Western Medicine Hubei Academy of Traditional Chinese Medicine and Pharmacy, Wuhan 430074 )HUNANG Su-qiu JIANG Zhao-ci (Dept of Chemistry. Wuhan Univ., Wuhan 430072 );STUDY ON THE MECHANISM OF PHOTODYNAMIC EFFECTS OF SYNTHETIC PROPHYRIN PN-5FU[J];Chinese Journal of Cancer;1993-06
2 MA Shan feng,LU Zong lan,GUAN Su dong,LIU Gui lan (Department of Physiology,Bengbu Medical College,Anhui 233003 ,China) [;Antagonistic effect of gypenoside on diaphragm against doxorubicin cytotoxicity[J];JOURNAL OF BENGBU MEDICINAE COLLEGE;2000-05
3 ZHANG Jin,WANG Chang-jun,XIE Jiang,CHEN Fang(Faculty of Pharmacology,Bengbu Medical College,Bengbu 233030,China);Protective effect of gypenosides on adriamycin induced acute cardiotoxicity in rats[J];Journal of Bengbu Medical College;2007-04
4 Zhang Mianzhi et al ( Hebei Medical University );Experimental Research of Chongcao Dihuang Promoting-blood-circulation Decoction for Atherosclerosis[J];China Journal of Traditional Chinese Medicine and Pharmacy;2003-04
5 $$$$;Preliminary study of the effect of gypenoside and AWS on the gentamicin-induced damages in cultured renal tubular epithelial cells[J];ACTA ACADEMIAE MEDICINAE MILITARIS TERTIAE;1996-02
6 HOU Xiao-Ping; JIA Guo-Liang; ZhAOKuan; JIA Guang-Xing;; DA Ji-Ping(Department of Cardiovasology, Xijing Hospital,Fourth Military Medical University, Xi'an 710033)(General Hospital of Air Force,PLA);Effects of gypenosides on intimal proliferation and expression of c-sis oncogene in rabbit iliac artery afterballoon deendothelialization[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1998-05
7 Wang Naiping,Wei Jinbin,Zang Linquan (Guangxi College of Traditional Ch inese Medicine,Nanning 530001,China);EFFECTS OF MEPYRAMINE ON THE MEMBRANE FLUIDITY OF HEPATIC MICROSOME IN LIVER DISEASES[J];Journal of Guangxi Medical University;2000-06
8 ;The summaries on the effect of bio-active components from natural products therapy for hyperlipidemia[J];Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology;2002-12
9 Liao DuanFang, Department of Pharmacology and Physiology, Hengyang Medical College;Effect of Gypenosides Against Oxidative Damage Part I, Influence of Gypenosides on Free Radicals Induced Injury of Guinea Pig Papillary Muscles And Rabbit Arterial Endothelium in Vitro[J];;1993-01
10 Chen Jian-Xiong,et al Department of Pharmacology;Protective Effect of Gypenosides on Free Radical Injury in Isolated Guinea Pig Hearts[J];;1993-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 XIANG Yan(Anhui Agricultural University,Hefei 230036);Effects of Hormone on Growth and Isozymes Activity of Gynostemma Callus in Vitro[J];AUHUI AGRICULTURAL SCIENCE BULLETIN;1999-03
2 Sun Feng et al (Wuhe Extension Center of Agriculture Technique, Wuhe 233300);Effect of Moisture in Soil on Jiaokulan Tea Growth[J];Journal of Anhui Agricultural Sciences;2001-02
3 Yuan Jing,Wu Huaqiang,Zhang Jinghu,Hou Zhengming,Cheng Quanzhu, Zhang Fuqing,Song Xiaoge,Tang Zhaoliang (Anhui College of TCM,Hefei 230038,China);THE INFLUENCE OF ZHECHONG ON BLOOD RHEOLOGY AND RED CELL IMMUNE FUNCTION IN CHRONIC BLOOD STASIS RATS MODEL[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-01
4 NIE Song liu,XU Xian xiang,XIA Lun zhu (Hospital of Lu′an City,Anhui Lu′an 237000,China);EFFECT OF TOTAL SAPONINS OF CODONOPSIS ON BLOOD LIPID AND NITRIC OXIDE LEVEL IN EXPERIMENTAL HYPERLIPEMIA RATS[J];Journal of Anhui Traditional Chinese Medical College;2002-04
5 ZHANG Hui yuan,YU Sheng zhu,ZHANG Min (Department of Traditional Chinese Medicine,the General Hospital of Lanzhou Military Region,Gansu Lanzhou 730050,China);Effect of Zhengzhi Pill on Production of Nitric Oxide and Endothelin by Human Endothelial Cells[J];Journal of Anhui Traditional Chinese Medical College;2003-01
6 Li Chun Zhou Liren (Department of Bioengineering,Anhui Agricultural University,Hefei 230036);Effects of Hormone on the Peroxidase and the Content of Gypenoside in Gynostemma Callus[J];JOURNAL OF ANHUI AGRICULTURAL UNIVERSITY;1998-04
7 Chen Qianfen;Tian Hecun;Zhang Chenyin;Chu Dekai;Yang Weidong(Department of Pathophysilolgy,Bengbu Medical College,Anhui 233003);Protective effect of gypenosides on global cerebral ischemia-reperfusion injury in rat[J];ACTA ACADEMIAE MEDICINAE BENGBU;1996-06
8 Hong Xingqiu, et al(Institute of Molecular Medicine, Hangzhou 310009);Experimental Study of Pinellia Tuber on Reducing Blood-Lipid[J];Journal of Zhejiang College of Tcm;1995-02
9 Wu Weping, et al(Department of Neurology, Chinese PLA General Hospital, Beijing 100853);The comparison between radix salviae miltiorrhizae(RSM )and nisoldipine nifedipine on the effect of antiperoxidation of low density lipoprotein[J];BEIJING MEDICAL JOURNAL;1995-03
10 Zheng Qizhi,Wu Jiaxiang,Xiao Renqiu,Wang Xinrui,Shi Bo,Wei Yongdi (Department of Pathology,School of Basic Medical Sciences);Effects of soyasaponin on cultured smooth muscle cell lipid peroxidation induced by insulin[J];Journal of Norman Bethune University of Medical Science;1998-05
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Sun Wansen,Wu Xili,Qiao Chenglin The Second Hospital Attached to Xi'an Jiaotong University,Xi'an (710004);Clinical Study of Gypenodide on Therapeutic Chronic Renal Failure[J];Journal of Zhejiang College of Tcm;2004-02
2 GAO Jing, LIU Yin,XU Meilin,et al. Dept. of Cardiology, Chest Hospital,Tianjing 300051;Study on dosimetry of endovascular brachytherapy with ~(32)P to prevent restenosis after angioplasty[J];Foreing Med Sci Sect Cardiovusc Dis;2005-01
3 ;Study Progresss in Dependability of Sex Hormone and Cerebral Infarction[J];Guiding Journal of TCM;2006-03
4 ZHANG Jin-yu,GUAN Li-ke (Yanbian University Hospital,Yanji 133000,China);Accommodation effects of black sesame oil on blood lipid in rabbit with atherosclerosis[J];Jilin Medical Journal;2007-01
5 YUE Xin, PAN Qi-Xing, ZHANG Wei, LI Ji-Fu, LI Gui-Shuang, CHEN Yu-Guo, and XU Fu-Yu(Department of Cardiology, the Qilu Hospital of Shandong University, Jinan 250012, China);Probucol Inhibit the Expression of Collagen TypeⅠ and C-myc Gene in the Injured Artery After Coronary Angioplasty in a Swine Model[J];Chinese Journal of Arteriosclerosis;2006-05
6 MEI Bin,ZHANG Jun-Jian,and LIU Yu-Min(Department of Neurology,the Zhongnan Hospital of Wuhan University,Wuhan 430071,China);Effect of Probucol on Restenosis and Growth Factors After Balloon Angioplasty in Rabbits Carotid Artery[J];Chinese Journal of Arteriosclerosis;2008-10
7 ZHANG Yong,SHANG De-jing,LI Qing-wei (College of Life Science,Liaoning Normal University, Dalian 116029,China);The Progress of Research in Reducing Blood Lipid by Traditional Chinese Medicine[J];Journal of Liaoning Normal University(Natural Science Edition);2004-02
8 ;普罗布考抗动脉粥样硬化作用机制及研究进展[J];Chinese Journal of Practical Internal Medicine;2007-09
9 GE Min1,LIU Tong2,GUAN Su-dong3,MA Shan-feng3,WU Ying-liang1 (1.School of Pharmay,Shenyang Pharmaceutical University,Shengyang 110016,China;2.Pharmacological Laboratory,Liaoning Institute for Drug Control,Shenyang 110023,China;3.Bengbu Medical College,Bengbu 233030,China);Effects of gypenosides on cardiac function in diabetic cardiomyopathy rats[J];Journal of Shenyang Pharmaceutical University;2007-06
10 Gao Xiaoge, Cui Wei (Tianjin First Central Hospital, Tianjin 300192);Studies on some Traditional Chinese Medicine with Efficacy of Protecting Vascular Endothelial Cell[J];Tianjin Pharmacy;2003-02
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Department of Cardiology,People’s Hospital Wang Bingyin,et al;AN OBSERVATION OF ANTIATHEROGENIC EFFECTS OF L-ARGINING I HYPERCHOLESTEROLEMIC RABBIT[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1994-03
2 YANG Ai-Lian; TANG Xiao-Qing; WANG XiaoPing; CHEN Yang-Fan; WANG La-Xiang; OU HeSheng; HUANG Zong-Zhi; PENG Jian-Ping; LIU Ge-Xiu; ZHANG Tong and YANG He-Ping(Molecular Biology Center, Hengyang Medical College,Hengyang 421001, China );L-Arginine Improves Endothelium Dependent Vasorelaxation and Reduces the Development of Proliferative atherosclerotic lesions[J];Chinese Journal of Arteriosc Lerosis;1995-01
3 TAN Xiao-Jin; DAI Ai-Guo; WEN Fang; LIAO Wen-Fu(Department of Internal Wedicine. First Affiliated Hospi tal) YANG He-Ping; ZOU Fei-Yan(Institute of Cardiovascular Disease, Hengyang Medical College, Hengyang, 421001)ZUO Gen-Ming(Hengyang Center Hospital,Ch;Effects of L-arginine on Serum Lipid,Lipoprotein, Apolipoprotein, Lipid Peroxide and Hemorheology in Patients with Coronary Heart Disease and Hyperlipemia[J];CHINESE JOURNAL OF ARTERIOSC LEROSIS;1997-01
4 YANG Yong-Zong; CHEN Yan-Fang; LIU Yi-Lin; LIN Xu-Guang; JIAO Hong-Li; WANG Zhou-Lian; DIN Cui-Fen; WAN La-Xian; YANG He-Ping (Molecular Biology Center, The Second Affiliated Hospital, Hengyang Medical College, Hengyang 421001; Guangdong Institute of Card;Effect of L-arginine on Lipoprotein, Nitric Oxide and Lipid Peroxide in Hypercholesterolaemic Rabbits[J];CHINESE JOURNAL OF ARTERIOSC LEROSIS;1995-03
5 Ma Xingfu, et al(Department of Pharmacology);THE ULTRASTRUCTURE STUDY ON EFFECTS OF GYPENOSIDES ON PLATELET FUNCTION IN RABBITS[J];Journal of Xi'an Jiaotong University(Medical Sciences);1988-04
6 Xin Dongsheng;Li Donghui Department of Pharmacology;STUDY OF EFFECTS OF GYPENOSIDES ON ANTI-MYOCARDIAL ISCHEMIA[J];Journal of Xi'an Jiaotong University (Medical Sciences);1991-02
7 Li Lin & Jin Youyu (Dept. of Pharmacology, Capital Institute of Medicine, Beijing);THE INFLUENCE OF JIAOGULAN EXTRACT ON PLATELET AGGREGATION AND ARACHIDONATE METABOLISM IN RABBITS[J];Chinese Pharmacological Bulletin;1989-04
8 Chen Chao , Fang Dachao ( Dept. of Pharmacology, Tongji Medical University, Wuhan 430030 )Department of Pharmacology,Yichang Medical College,Hubei 443003;EFFECTS OF PALMATINE ON ELECTROPHYSIOLOGICAL CHARACTER IN THE ISOLATED GUINEA PIG PAPILLARY MUSCLES[J];Chinese Pharmacological Bulletin;1991-02
9 Li Lin1, Xing Shantian, Zhou Jinhuang ( Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850);PROTECTIVE EFFECTS OF GYPENOSIDES ON RAT HEPATIC LIPID PEROXIDATION AND MEMBRANE FLUIDITY DAMAGE: IN VITRO STUDIES[J];Chinese Pharmacological Bulletin;1991-05
10 IU Li-Bo,HU Bi,LIAO Duan-Fang1 (Dept of Physiology; 1Dept of Pharmacology, Hengyang Medical College,Hunan 421001);Protective effect of gypenosides on free radical damage of isolated guinea pig papillary muscles[J];Chinese Pharmacological Bulletin;1993-04
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