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《Chinese Journal of Arterial Lerosis》 2005-05
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Effects of Rosiglitazone on the Levels of Nitric Oxide and Endothelin in Rats with Insulin Resistance

LING Hong-Yan~~(1,2),HU Bi-Li~2,FENG Shui-Dong~3,ZHOU Shou-Hong~2,HE Jian-Qin~2,YANG Si-Si~2,and HU Bi~2(1.Department of Phamacology,Central South University,Changsha 410078;2.Department of Physiology,3.Department of Epidemiology,Nanhua University,Hengyang 421001;China)  
Aim To investigate the effect of rosiglitazone on the blood levels of nitric oxide(NO)and endothelin-1(ET-1) in insulin resistant rats and the underlying mechanism.Methods Male Sprague-Dawley(SD) rats were fed with high fructose to induce insulin resistant rats model,rats were treated with or without rosiglitazone after 4 weeks.At the end of 8th week,systolic blood pressure(SBP),fasting blood sugar(FBS),fasting serum insulin(FSI),blood lipids,NO,ET-1 and aortic nitric oxide synthase(NOS) activity were measured respectively in groups.Results Compared with control group,SBP,FSI and ET-1 in model group significantly increased;aortic NOS activity and NO levels were significantly lowered.At the same time,the abnormity of lipid metabolism appeared in the model group.After rosiglitazone treatment,SBP,FSI and ET-1 remarkably reduced;aortic NOS activity and NO levels significantly increased;insulin resistance and the abnormity of lipid metabolism were improved.While all indexes did not change significantly after rosiglitazone treated control rats.Conclusions Rosiglitazone may improve vascular endothelial function in rats with insulin resistance by decreasing blood pressure,increasing insulin sensitivity,improving the abnormity of lipid metabolism,besides,it could be associated with nitric oxide elevating by increasing nitric oxide synthase activity and inhibiting endothelin increasing.
【Fund】: 湖南省自然科学基金(01JJY2147)资助
【CateGory Index】: R96
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 LI Wei 1, WU Zhi Yong 1, Gerald M Reaven 2, and Philip S Tsao 2 (1.Medical and Rehibilitation Center, Hainan Provincial People's Hospital, Haikou 570311, China; 2.Cardiovascular Research Center, Stanford University School of Medicine, Stanford CA 9;Changes of Mononuclear Cell Adherence to Endothelium in Hypertensive and Insulin Resistant Patients[J];Chinese Journal of Arteriosc Lerosis;2002-02
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 LING Hong - yan, FENG Shui - dong, WANG Bing - xiang, et al (Department of Physiology & Epidemiology, Nanhua University, Hengyang, Hunan 421001, China);Study of Mechanism of Aortic Endothelial Function in Rats With Insulin Resistance[J];Journal of Nanhua University(Medical Edition);2004-04
2 LING Hong-Yan, WEN Jing-Sheng, ZHOU Shou-Hong, LONG Guang, LI Liang, and HU Bi (Department of Physiology, NanHua University, Hengyang 421001, China);The Effects of Rosiglitazone on Sugar and Lipid Metabolism in Fructose-Fed Renal Hypertensive Rats[J];Chinese Journal of Arterial Lerosis;2003-06
3 PAN Xiao-Ming,WU Zong-Gui,HUANG Zuo,REN Yu-Sheng,ZHANG Jia-You,and LI Hong-Tao (Department of Cardiology, Changzheng Hospital, Shanghai 200003, China);The Effects of Insulin on Expression and Secretion of Tumor Necrosis Factor-α Protein of Human Peripheral Blood Mononuclear Cells and the Intervention Effects of Pravastatin[J];Chinese Journal of Arterial Lerosis;2004-05
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1 TIAN Guo-Ping (Department of Cardiology, the Second Affiliated Hospital of Nanhua Medical University, HengYang 421001, China);Effects of Potassium Magnesium Aspartate on Insulin Resistance in Essential Hypertension[J];Chinese Journal of Arteriosc Lerosis;2000-04
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