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The Association of Lipoproteins Subfractions with Intimal Medial Thickness of Carotid Artery in Type 2 Diabetic Patients

SUN Ming-Xiao1,2,GUO Han-Bang3,JIANG Lei2,DONG Jun3,WANG Shu3,and CHEN Wen-Xiang3 (1.Graduate School,Bejing Sports University;2.Department of Endocrinology and Metabolism,Beijing Hospital;3.Institute of Geriatrics,Beijing,100730,China)  
Aim To investigate the association of lipoproteins subfractions with intimal medial thickness(IMT) of carotid artery in type 2 diabetic patients. Methods The subfractions of lipoproteins were determined by ultracentrifugation and high-performance liquid chromatiography,and the IMT of both sides carotid artery were measured by B-mode ultrasonography in 55 type 2 diabetic patients,divided into two groups by the IMT 1.2 mm(n=20) and ≤1.2 mm(n=35).The relationship between the lipoprotein subfractions and IMT was investigated. Result The older age was more common in patients with IMT1.2 mm compared to those with IMT≤1.2 mm(P0.05).The serum level of lipoprotein(a) was higher in group IMT1.2 mm(0.122±0.077 mmol/L vs 0.081±0.049 mmol/L,P0.05).After adjusting the age,sex and BMI,the higher IMT was positively correlated with Lp(a) and LDLb;Lp(a) was positively correlated with LDL;TG was positively correlated with fasting blood glucose and LDLb,inverse correlated with HDL、HDL2 and LDLa(P0.05). With stepwise multivariate logistic regression analysis,older age and Lp(a) were identified as significant and independent risk factors for higher IMT of carotid artery in type 2 diabetic patients(P0.001 and P=0.021 respectively). Conclusion The results suggest that Lp(a) has a strong association with IMT of carotid arteries and might be the important predictor for early atherosclerosis in type 2 diabetic patients.
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