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《Chinese Journal of Arteriosclerosis》 2009-02
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Ginseng Polysauharides Interfering Changes of Lipid Peroxidation During Hepatic Ischemia Reperfusion in Rabbits

ZHENG Yan-Rong1,SHI Lu2,YAN Wan-Xin3,JIA Xu-Guang2,CHEN Liang3,LIANG Ying-Qi2,and WANG Wan-Tie2(1.Disease Prevention and Control Center of Wenzhou,Wenzhou 325027; 2.Department of Pathophysiology,Wenzhou Medical College,Wenzhou 325035; 3.Surgical Department,The 3rd People's Hospital of Wenzhou,Wenzhou 325000,China)  
Aim To explore the effect of Ginseng polysauharides on changes of lipid peroxidation in hepatic ischemia reperfusion injury and its mechanism. Methods 30 rabbits were randomly divided into control group,ischemia-reperfusion (IR) group and Ginseng polysauharides group. Alanine aminotransferase (ALT),superoxide dismutase (SOD),glutathione peroxidase(GSH-Px),xanthine oxidase(XO),malondialchehyche (MDA) were recorded,and the liver organizational structure change were observed under the light microscope. Results In IR group,the plasma SOD,GSH-Px activity declined gradually 45 minutes after ischemia and this phenomenon continued for 45 minutes after reperfusion. The activity of ALT,XO and the content of MDA clearly increased. In Ginseng polysauharides group,the plasma SOD,GSH-Px activity had no prominent decline; the activity of ALT,XO and content of MDA had no obvious increase,especially when 45 minutes after reperfusion,the SOD activity was much higher,and the ALT and XO activity,content of MDA were much lower than that in IR group of the same period (P0.01). The SOD and GSH-Px activity of IR group in liver increased compared with control group,but decreased in Ginsen polysauharide group compared with IR group (P0.01). The XO activity and the MDA content of the IR group in liver decreased compared with control group,but increased in Ginsen polysauharide group compared with IR group (P0.05 or 0.01). In IR group,the morphology structure of hepatic cell obviously abnormal,but in Ginseng polysauharides group,relatively mild injury occurred to the hepar. Conclusion Ginseng polysauharides can reduce the activity of XO and suppress the production of oxygen-derived free radicals; tone up antioxidase like SOD,GSH-Px and suppress lipid peroxidization,thus effectively reduce the injury caused by hepatic ischemia reperfusion.
【Fund】: 温州市科技局资助项目(Y20060195)
【CateGory Index】: R285.5
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2 JIA Lin,WO Xing-de,LU Jin-jian,WANG Mi-mi,ZHU Xiao-song(College of Life Sciences,Zhejiang Chinese Medicine University,Hangzhou 310053,China);Extraction and purification of polysaccharides from Platycodon grandiflorum A.DC[J];Journal of Biology;2011-02
3 SONG Li-hua1,3,XIAO Wei2,3,LU Li-li1,3,WANG Zhen-zhong2,3,JIANG Hua2,3,ZHANG Yi2,3,ZHU Ke-jin2,3 1.Nanjing University of Chinese Medicine,Nanjing 210000,China 2.Jiangsu Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222001,China 3.State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process,Lianyungang 222001,China;Extracting technology optimization of polysaccharides from Panax ginseng by orthogonal test[J];Chinese Traditional and Herbal Drugs;2012-02
4 CHEN Liang1,TANG Lan-lan2,YAN Wang-xin1,ZHANG Yan-hua2,WANG Shu-jun2, LI Guan-long2,WANG Yuan-yuan2,WANG Wan-tie2(1.Surgical department,The 3rd People's Hospital of Wenzhou,Wenzhou 325000,Zhejiang,China; 2.Department of Pathophysiology,Wenzhou medical college,Wenzhou 325035,Zhejiang,China);The Improvement of Ginseng Polysauharides Against Hepatic Reperfusion Injury on Energy Metabolism in Rabbits and Its Mechanism[J];Chinese Archives of Traditional Chinese Medicine;2011-05
5 ZHNAG Fu-zhi1,SHI Lu2,HAO Mao-lin2,WANG Wei2,WANG Wan-tie2(1.The People's Hospital of Pingyang,Pingyang 325400,China;2.Wenzhou Medical College,Wenzhou 325035,China);The Effect of Puerarin on Serum Interleukin-1β and Tumor Necrosis Factor-alpha of Rabbits with Hepatic Ischemia-reperfusion Injury[J];Acta Chinese Medicine and Pharmacology;2011-02
6 SONG Li-hua1,3,WANG Hong-mei2,3,XIAO Wei2,3(1.Nanjing University of TraditionaL Chinese Medicine,Nanjing 210000,China; 2.Jiangsu Kanion pharmaceuticaL CO.,LTD,Lianyungang 222013,China; 3.State Key Laboratory of New-tech for Chinese Medicine PharmaceuticaL Process,Lianyungang 222001,China);Fractionation of Ginseng Polysaccharides and Primary Study of Immune Activity[J];Chinese Journal of Experimental Traditional Medical Formulae;2012-14
Chinese Journal Full-text Database 2 Hits
1 WANG Wantie 1,WANG Wei 1,XU Zhengjie 1,LIN Lina 2,LI Dong 3.1.Department of Pathophysiology,Wenzhou Medical College,Wenzhou 325027,Zhejiang,China;Role of lipid peroxidation in hepatic ischemia-reperfusion injury and effect of L-Arginine[J];Chinese Critical Care Medicine;2003-02
2 ZHAO Jian-ping WANG Yuan-yuan Department of Respiratory Disease,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan(430030);Experimental Study of the A549 Cell Apoptosis of Human Non-small Cell Lung Cancer Induced by Ginseng Polysaccharide in vitro[J];Chinese Journal of Integrated Traditional and Western Medicine;2006-S1
Chinese Journal Full-text Database 10 Hits
1 PENG Shu-hui et al(Guangzhou City Polytechnic,Guangzhou,Guangdong 510405);Research Progress of Functional Polysaccharose[J];Journal of Anhui Agricultural Sciences;2010-19
2 BAI Xue-yuan et al(Changchun University of Medicine,Changchun,Jilin 130117);A Comparative Study on Sugar Content in Different Varieties of Ginseng Grown for Different Years[J];Journal of Anhui Agricultural Sciences;2012-01
3 SHAN FENG,HE JUN-FENG,SONG NUAN,et al(Department of Intensive Care Unit,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);;THE PROTECTIVE EFFECT OF VERAPAMIL AND SHENGMAI INJECTION ON ISCHEMIA-REPERFUSION LIVER INJURY IN RATS[J];Acta Academiae Medicinae Qingdao Universitatis;2008-05
4 Xu Haishun,Jiang Jianping,Xu Pan,et al Zhejiang Chinese Medical University,Hangzhou(310053);Antioxidant Activity of Polysaccharide from Radix Ginseng Rubra[J];Journal of Zhejiang Chinese Medical University;2011-06
5 WANG Dan,LV Yong-lei,XU Li-yuan,BU Hai-bo,LI Xiang-ri(School of Chinese Materia Medica,Beijing University of Traditional Chinese Medicine,Beijing 100102,China);Content Determination of Polysaccharide in the root of Panax ginseng[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-04
6 ZHU Mei1,BI Hong-tao2,YANG Wei2,LIU Yang2,TAI Gui-hua2,ZHOU Yi-fa2(1.College of Chemistry and Biology,Beihua University,Jilin 132013,China;2.School of Life Sciences,Northeast Normal University,Changchun 130024,China);The effects of ethanol concentrations on isolation of ginseng polysaccharides[J];Journal of Northeast Normal University(Natural Science Edition);2009-02
7 Zhang Xiao-yan,Xu Zeng-rong,Hu Hong-wei,et al. (Heilongjiang University of Chinese Medicine,Harbin 150040,China);Study on the Anti-tumor Effect of Anti-cancer Element as Colon Targeting Dropping Pill[J];Chinese Journal of Medicinal Guide;2010-03
8 LV Feng,YANG Cai-xia,JIANG Yan-mei,HUANG Yi-fan(College of Food Science,Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002,China);Health and processing qualities of Chinese Coix lachryma-jobi kernel[J];Journal of Fujian Agriculture and Forestry University(Natural Science Edition);2008-04
9 LIANG Yingqi,ZHENG Yanrong,WANG Wantie,et al. Department of Pathophysiology,Wenzhou Med-ical College,Wenzhou 325035;Effects of Ginseng Polysauharides on NO,ET and ALT in hepatic ischemia reperfusion of rabbits[J];Journal of Hepatopancreatobiliary Surgery;2009-01
10 ZHOU Mengtao,SUN Hongwei,JIN Yuepeng,et al.Department of Hepatobiliary & Pancreatic Surgery,the First Affiliated Hospital,Wenzhou Medical College,WenZhou 325000;Application of primary common bile duct closure after choledochotomy in biliary surgery[J];Journal of Hepatopancreatobiliary Surgery;2009-01
China Proceedings of conference Full-text Database 1 Hits
1 WEI Shou-rong, XUE Cun-kuan, HE Xue-bing, SHEN Kai, YUAN Bing, JIANG Peng, ZHU Jun, LI Ying, ZENG Ling Geriatric Institute, Liyuan Hospital, Tongji Medical College, Huazhong Science and Technology University ( Wuhan Hubei, 430077);Effects of Gynostemma polysaccharides(GP)on blood glucose[A];[C];2005
Chinese Journal Full-text Database 10 Hits
1 TANG Xu dong, JIANG Jian qing, LIU Bao yu,ZHOU Kai,DING Sheng,YU Yong kang (Department of Thoracic and Cardiovascular Surgery,the General Hospital of Chengdu Military Region,PLA,Sichuan Chengdu 610083,China);Molecular Mechanism of Protective Effect of Total Saponins of Panax Notoginseny against Myocardial Ischemia Reperfusion Injury[J];Journal of Anhui Traditional Chinese Medical College;2003-01
2 ZHAO Dong,WANG Tian-long~△,PAN Fang,ZHAO Lei,ZHANG Lian-feng,YANG Ba-xian(Department of Anesthesia,Peking University People's Hospital,Beijing 100044,China);Changes in hemodynamics and oxygen metabolism of different Child-grade patients during orthotopic liver transplantation without veno-venous bypass[J];Journal of Peking University(Health Sciences);2006-04
3 HAN Feng,ZHOU Jin-xue,ZHANG Lin,et al.Department of Hepatobiliary Surgery,Henan Tumor Hospital,Zhengzhou 450008,China;The protection of panax notoginseng saponins against ischemia reperfusion injury by liver graft in rats[J];Journal of Chinese Physician;2005-12
4 XIE Kang, HUANG Yue sheng (State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burns, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Effects of ulinastatin on inflammatory cytokines in blood serum of rats after severe burn and the significance[J];Acta Academiae Medicinae Militaris Tertiae;2004-18
5 Deng Jia,Li Changyi,Wang Daoxin (Department of Respiratory Diseases,Second Affiliated Hospital,Chongqing Medical University,Chongqing,400010,China);Effect of ulinastatin on expression of ENaC-β mRNA and protein in A549 cells treated with TNF-α[J];Acta Academiae Medicinae Militaris Tertiae;2010-09
6 LI Zhi-min,WANG Bo-chu,ZHOU Jing, PENG Liang nistry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China);Comparison of three methods of removing protein from polysaccharide extract in the plant[J];Journal of Chongqing University(Natural Science Edition);2004-08
7 LIAO Xiu-qing,XIONG Ping,XIAO Xiao-san.Second People's Hospital,Guangzhou 510317,China;Protection of lung ischemia/reperfusion injury in rats by astragaloside[J];Guangdong Medical Journal;2009-12
8 Shi Guangfeng, Li Qian, Wang Xinhua, et al. Department of Infectious Diseases, Huashan Hospital, Fu Dan University, Shanghai 200040, China;Effects of Oxymatrine on the expression of tissue inhibitor of metalloproteinase-1 and α-smooth muscle actin in the livers of rats with carbon tetrachloride-induced fibrosis.[J];Journal of Clinical Hepatology;2003-03
9 Wang Chenyong,N i Yong,L iu yan,et al.Department of Surgery Shen Zhen Second H ospital,Shen Zhen 5 180 35;EXPERIMENTAL STUDY OF INJURY AND IT’S MECHANISM IN TH E ISCHEMIA AND REPERFUSION PERIOD IN RABBIT L IVER[J];Journal of Hepatobiliary Surgery;2002-06
10 WANG Wei~*,XU Dong-wu,WANG Wan-tie~*,et al.* Department of Pathophysiology,Wenzhou Medical College,Wenzhou 325027;Effect of puerariae on NO,ET-1 in rabbits following hepatic ischemia reperfusion injury[J];Journal of Hepatopancreatobiliary Surgery;2006-03
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 CHEN Hong-yang,WANG Kang-yu,WANG Yi,ZHANG Mei-ping,JIANG Shi-cui,SUN Chun-yu(Jilin Agricultural University,Changchun 130118,China);Comparison of two protein-removing methods in the extraction process of ginseng soluble sugar[J];Guangdong Agricultural Sciences;2013-07
2 SONG Ming-ming et al ( Institute of Materia Medica of Dalian University,Dalian,Liaoning 116622);Extracting Technology Optimization of Total Flavonoids from the Leaves of Engelhardtia roxburghiana Wal.by Orthogonal Test[J];Journal of Anhui Agricultural Sciences;2013-14
3 LIU Jia-qi;Institute of Material Medical,Dalian University;;The Optimum Technique for Extracting Total Flavonoids from Smilax glabra Roxb. by Orthogonal Test[J];Journal of Anhui Agricultural Sciences;2013-17
4 JIA Lin LU Jin-jian ZHOU Wen-ya SHI Jia-jie WO Xing-de (College of Life-Science,Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310053,China);Immunoregulatory effect of polysaccharides from Platycodon grandiflorum A.DC on immunosuppressive mice induced by cyclophosphamide[J];Food & Machinery;2012-03
5 ZHENG Yan-rong1,CHEN Liang3,YAN Wang-xin3,CHEN Hai-e2,MA Ying-chun2,CHEN Dan2,WANG Wan-tie2 1 Centers for Disease Prevention and Control of Wenzhou,Wenzhou 325001,Zhejiang,China;2 Department of Pathophysiology,Wenzhou Medical College,Wenzhou 325035,Zhejiang,China;3 Department of Surgery,the Third People's Hospital of Wenzhou,Wenzhou 325000,Zhejiang,China;Regulating effects of Ginseng Polysauharides on balance between Thromboxance B_2 and Prostacyclin F_(1α) during hepatic ischemia/reperfusion injury in rabbits[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2012-05
6 Jia Lin, Lu Jinjian, Lu Dezhao, Shi Jiajie, Zhou Wenya, Wo Xingde (College of Life Sciences, Zhejiang Chinese Medical University, Hangzhou 310053);Purification and Content Determination of the Polysaccharides from Platycodon grandiflorum[J];Chinese Agricultural Science Bulletin;2011-17
7 GE Ya-long,YANG Heng-tuo,YU Fan,LIU Cun-fang(School of Chemical and Environment Science,Shaanxi University of Technology,Hanzhong 723000,China);Optimization of Microwave Extraction Technology and Investigation of Antioxidant Activity for Polysaccharides from Seeds of Vicia villosa[J];Chinese Journal of Experimental Traditional Medical Formulae;2013-09
8 CUI Hong-hua,YU Zhi-cheng,SHEN Zhi-bin,WU Jie-ying,ZOU Zhong-jie(College of Chinese Traditional Medicine,Guangdong Phamaceutical University,Guangzhou 510006,China);Hepatoprotective Effect of Dicliptera chinensis Polysaccharide with Diffent Molecular Weight on Carbon Tetrachloride-induced Acute Liver Injury in Rats[J];Chinese Journal of Experimental Traditional Medical Formulae;2013-09
9 Li Ting 1,Xu Wenshan 1,Li Xiwen 1,Chen Xiuping 1,Lu Jinjian 1,2(1 State Key laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao;2 College of Life Sciences,Zhejiang Chinese Medical University,Hangzhou 310053);Advances in pharmacological studies of Platycodon grandiflorum[J];Pharmacology and Clinics of Chinese Materia Medica;2013-02
10 BAI Xue-yuan,SUN Li-xia,CHANG Gui-juan,YANG Ji-ping,ZHAO Yu,ZHAO Da-qing(Changchun University of TCM,Changchun 130117,China);Content Determination of Saponins and Total Polysaccharide in Shenwei Soft Capsules[J];China Pharmacy;2013-23
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 HUANG Huowen,ZHANG Bei,XU Boping, CHEN Xuxian (Traditional Chinese Medicine Department, Tumor Hospital, Sun Yat-sen University of Medical Sciences,Guangzhou 510060) [;CLINICAL STUDY ON PROTECTIVE ACTION OF SHEN-QI INJECTION IN PATIENTS WITH NPC RECEIVING RADIOTHERAPY[J];CHINESE JOURNAL OF CANCER;1994-06
3 Zhang Ming, Li Xiuyi, Li Fenglan, Lu Ligong (Department of Radiobiology);Effect of panaxatriol on the content of plasma insulin in X-irradiated rats[J];;1993-06
4 JIN Guang hui 1,LIU Shu zheng 1,LIU Yang 1,LI Xiao kun 2,MA Xing yuan 3 (1. MH Radiobiology Research Unit,Jilin university,Changchun 130021 China; 2. Institue of Bioengineering,Jinan University; 3. Dept.of Organic Chemistry,Jinlin university);Study on protective mechanism of PT,VitE and VitC from skin damage induced by ultraviolet radiation[J];Journal of Norman Bethune University of Medical Science;2002-01
5 LIU Li bo 1,SUN Xiao ling 1,ZHANG Hai ying 1,LIANG Shuo 1, MA Xing yuan 2,LI Xiao kun 3,LIU Shu zheng 1 (1. Institute of Radiation Medicine,Jilin University, Changchun 130021 China; 2. Dept.of Organic Chemistry,Jilin University; 3. Institu;Radioprotective effect of panaxatriol on chromosome of bone marrow cells in mouse[J];Journal of Norman Bethune University of Medical Science;2002-02
6 Liu Weihong,Gong Shouliang,Li Xinmin, Liu Shuzheng (Deparment of Radiation Biology);Radioprotective effect of Panaxatriol on immune organs in male rats[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1994-01
7 Fu Pingping,Gao Qipin,Wang Weizhang, Jiang rui zhi, et al(Dept. of 3th Teacling Hospital,Academy of Traditonal Chinese Medicine Medica of Jilin Prouince);Chemical properties and anti-tumoractivity of polysaccharides from roots of ranax ginseng[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1994-05
8 Liu Libo,Kang Shunai ,Li Ling,et al (Dept.of Occupational Health,The School of Protective Medicine);Radioprotective effect of Ginsenoside on chromosome in bone marrow cells of male mouse[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1997-04
9 Zhang Yishen, Lie Renqiu and Wang Yuwan;AN INVESTIGATION OF PANAX GINSENG C.A. MEY POLYSACCHARIDE[J];Journal of Northeast Normal University;1982-02
10 WANG Yang, WANG Bo-chu,ZHOU Jing,PENG Liang ( Key Laboratooy for Biomechanics & Tissue Engineering under the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China);Investigatied Development on Immune Regulation of Polysaccharide[J];Journal of Chongqing University(Natural Science Edition);2004-03
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