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《Chinese Journal of Arteriosclerosis》 2012-12
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Role of Vascular Endothelial Cell Damage in Myocardial Injury in Septic Rats

XU Qiu-Lin1,LIU Jing-Xian1,GUO Xiao-Hua2,LIU Zhi-Feng1,TANG You-Qing1,LIU Yun-Song1,and SU Lei1 (1.General Hospital of Guangzhou Military Command,Guangzhou,Guangdong 510010,China;2.Department of Pathophysiology,Southern Medical University,Guangzhou,Guangdong 510515,China)  
Aim To investigate the role of endothelial damage related to septic myocardial injury. Methods30 Sprague-Dawley rats were divided into 3 groups: sham-operation group,sepsis group and ulinastatin group.Plasma von Willebrand factor(vWF) and thrombomodulin(TM) levels were detected with ELISA,plasma creatine kinase(CK) and creatine kinase isoenzyme(CK-MB) levels with reflotron plus clinical chemistry analyser,left ventricular pressure(LVP),the maximum and minimum rates of LVP change(+dp/dtmax and-dp/dtmax) by cardiac catheterization and brain natriuretic peptide(BNP) levels by Western blot. Results Plasma CK,CK-MB and cardiac BNP levels were elevated,LVP,+dp/dtmax and-dp/dtmax decreased as vWF and TM levels increased in sepsis group compared with those in sham-operation group.However,reduced myocardial injury and improved cardiac function were observed in ulinastatin group. Conclusion Endothelial damage in coronary probably contributes to sepsis induced myocardial injury.
【Fund】: 国家自然科学基金项目资助(81071529);; 广东省自然科学基金项目资助(9151001002000021.2009 01-2012 12)
【CateGory Index】: R459.7
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