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《Journal of Henan University(Medical Science)》 2006-03
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Protective effects of polysccharide sulfate on glutamate-induced neurotoxicity in cerebral cortical neuronal cultures

JI Bian-Sheng,JI Zhong-Qi (Department of pharmacology,Pharmaceutical College of Henan University,Kaifeng 475001,Henan,China)  
Objective: To investigate protective effects of polysccharide on glutamate-induced neurotoxicity in cerebral cortical neuronal cultures.Methods: The Cortical neurons of fetal of rat were cultured in vitro.The protective effects of PSS on glutamate-induced neurotoxicity were observed.Apoptosis was measured via flow cytometry,the intracellular calcium and caspase 3 activity were determined by fluorescent assay.Results: PSS50,100,150μg·ml~(-1) could reduce glutamateinduced cell death,efflux of LDH,elevation of MDA,intracellular \ accumulation and cell apoptosis as well as caspase 3 activity,in contrast, it increased the SOD activity.Conclusion: The protective effects on cerebral cortical neurons from ischemia injury have something to do with PSS,which can inhibit intracellular \ accumulation and suppress generation of lipid peroxide.
【CateGory Index】: R96
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