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《Journal of Henan University(Medical Science)》 2007-04
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On effects of simvastatin on human monocyte derived DCs mature and its on immunological functions

YIN Xue-liang1,HUI Xue-zhi2,LIU Jian-xiao1,LIANG Tian-shu1,ZHANG Hong2 (1.Zhongshan City Dongfeng Hospital of Kuangdong Province,Guangdong Zhongshan 528425,China;2.The First Affiliated Hospital of Henan University, Henan Kaifeng 475001,China)  
Objective: To investigate the effects of simvastatin on human monocyte derived DCs mature and its on immunological functions.Methods: Human monocytes were isolated by means of gradient centrifugation method,followed by 5 days'culture with DC Cellgro medium containing 100ng/ml rhGM-CSF and 20ng/ml rhlL-4.Mature DCs was then obtained.PBS and LPS were as the negative and positive control,and in experimental groups,antigen as 0x-LDL labelled with 50 μg/mlDil were added to the medium both to iucubate with DCs,while drug as 100 μmol/L simvastatin was only added to one group.FACS was used to investigate the immuno-phenotypic expression(CDI a,CD80,CD86 and HLA-DR)after 48 hours.The progress of phagocytosis was observed in microscope,and the effects of DCs on lymphocyte proliferation was observed by mixed T lymphocyte reaction.Results: Atorvastatin reduced DCs'immuno-phenotypic expressions of CD l a and HLA-DR,and inhibited DCs'Phagocytosis of 0x-LDL.Conclusion: Simvastatin can significantly inhibit immune activity and the function of phagocytosis of DCs,which shows a new immune regulating mechanism of statins series.
【Fund】: 广东省中山市科技攻关项目(206A039)
【CateGory Index】: R96
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