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《Chinese Journal of Infection and Chemotherapy》 2008-01
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CHINET 2006 surveillance of bacterial resistance in China

WANG Fu on behalf of CHINET Working Group. (Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China)  
Objective To investigate the resistance of clinical isolates from hospitals in several regions of China, in 2006.Methods Eight general hospitals and two children′s hospitals were involved in this program. Bacterial susceptibility testing was carried out according to an agreed protocol using Kirby-Bauer method. Results were analyzed according to CLSI 2006.Results A total of 33 945 clinical isolates were collected from January through December 2006, of which gram negative microorganisms and gram positive cocci accounted for 68.2% and 31.8% respectively. In the 202 strains of S. pneumonia from adults, 92.1%, 5.4%, 2.5% were identified as penicillin-susceptible (PSSP), -intermediate (PISP) and -resistant (PRSP), respectively. Of the 356 strains of S. pneumonia from children, 11.8%, 68.5% and 19.7% were PSSP, PISP and PRSP, respectively. Beta-lactamase production was positive in 25% of H. influenzae isolates. Methicillin resistant strains in S. aureus (MRSA) and MRCNS accounted for an average of 58.4% and 76.3% respectively. However, the prevalence of MRSA and MRCNS was only 12.4% and 3.8% respectively in the two children′s hospitals. No staphylococcal isolate was found resistant to vancomycin, teicoplanin or linezolid. On average, 51% of E. faecalis and 71% of E. faecium strains were resistant to high concentration gentamicin (120 μg/disc). Twelve vancomycin-resistant E. faecium (VRE) strains were isolated, 11 of which were van A type. About 51.7% (31%-67.4%) of E. coli, 45.2% (15.4%-67.`9%) of Klebsiella spp. (K. pneumoniae and K. oxytoca), and 18.1% of P. mirabilis isolates were ESBLs-producing strains. Isolates of Enterobacteriaceae were still highly sensitive to imipenem and meropenem. The average resistance rate was less than 1%. However, up to 30%-40% strains of P. aeruginosa and Acinetobacter spp. were resistant to the two carbapenems. Moreover, some multi-drug resistant and pan-resistant gram negative bacilli were found in these hospitals.Conclusions Bacterial resistance is still on the rise, especially with the appearance of MDR and pan-resistant gram negative strains. It is mandatory for each hospital to take effective measures to control the dissemination and outbreak of infections caused by MDR organisms.
【CateGory Index】: R446.5
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