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《Chinese Journal of Infection and Chemotherapy》 2009-02
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Antimicrobial resistance and extended-spectrum β-lactamases genotypes of Shigella isolates in Shanghai

ZHU Dong-an,SUN Jing-yong,FAN Hui-qing.(Department of Clinical Laboratory,Nanhui Central Hospital,Shanghai 201300,China)  
Objective To analyze the resistant pattern and the extended-spectrum β-lactamases genotypes of clinical isolates of Shigella in Shanghai.MethodsSusceptibility testing was performed by K-B disk diffusion method.Transferability of resistance to cefotaxime was examined by conjugation test.PCR method was employed to detect the genotypes of ESBLs-producing strains using CTX-M and SHV universal primers.The PCR products were analyzed by DNA sequencing.ResultsLess than 50% of these isolates were susceptible to nalidixic acid,ampicillin,ampicillin-sulbactam and trimethoprim-sulfamethoxazole.And 81.5% of these isolates were susceptible to cefotaxime.ESBLs were identified in 18.5%(40/216) of Shigella isolates and 87.5%(35/40) of them were conjugated to Escherichia coli J53 Azr.Most(90%,36/40) of ESBLs-producing strains were detected by CTX-M primers.The genotypes of these strains included CTX-M-14(20/40),CTX-M-15(13/40) and CTX-M-3(3/40).ConclusionsThe Shigella strains isolated in Shanghai were multi-drug resistant.The main genotypes of ESBLs were CTX-M-14,CTX-M-15 and CTX-M-3.
【Fund】: 上海市南汇区科委课题(NKYL0601)资助
【CateGory Index】: R446.5;R450
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