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《Bulletin of Science and Technology》 2002-05
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Hemoglobin Immobilized on Chitosan as Oxygen Carriers

MENG Wen fang 1, CAI Jin 2, YUAN Zhong yi 3 (1.The Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310016,China; 2.College of Chemical & Biochemistry Engineering,Zhejiang University,Hangzhou 310027,China; 3.Shanghai I  
Oxygen carriers based on immobilized hemoglobin are promising in aviation, space flight, underwater work and aerobic fermentation. This paper studied the mechanism of porcine hemoglobin (pHb) immobilization on chitosan activated by glutaraldehyde. The influences of activation condition on aldehyde group content and on the amount of immobilized pHb were observed. The activation processes and conditions were optimized. By the activation procedure that the chitosan was treated with 5% glutaraldehyde for 8 hours, the carrier thus obtained was able to immobilize maximum amount of pHb, i.e. about 800mg /g chitosan. The oxygen carrier showed the highest oxygen release efficacy of 40% and good stability.
【Fund】: 国家自然科学基金资助项目 ( 39880 0 0 6 )
【CateGory Index】: R313
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