Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Kunming Medical University》 2008-01
Add to Favorite Get Latest Update

Expression of Brn-3a and PPAR-γ in Cervical Neoplasia

HUANG Ya1),FENG Yu-kun2),LI Jian-jun1),YU Lu1)(1)Dept.of Obstetrics,The 1st People’s Hospital of Kunming,Kunming Yunnan 650011;2)Dept.of Obstetrics and Gynecology,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650031,China)  
Objective To investigate the expression and correlation of Brn-3a and PPAR-γ and explore the potential of Brn-3a and PPAR-γas biomarkers for cervical cancer(CC)and cervical intraepithelial neoplasia(CIN).Methods Immunohistochemistry method(Streptavidin-biotion method,S-P)was used to detect the expression of Brn-3a protein and PPAR-γprotein on 110 cases of cervical paraffin specimens.Results The expression rates of Brn-3a protein were 10.0%,45.0%,50.00%,55.0% and 76.7% in control,CINⅠ,CINⅡ,CINⅢ and SCC group respectively,Compared with control group,the expression of Brn-3a protein in SCC and CIN group were significantly higher(P 0.05).The expression rates of PPAR-γ protein were 5.0%,25.0%,40.0%,45.0% and 56.7% in control,CINⅠ,CINⅡ,CINⅢ and SCC group respectively.Compared with control group,the expression of PPAR-γprotein in SCC and CINⅢgroup were significantly higher(P 0.05).Compared with CINⅠgroup,the expression of PPAR-γprotein in SCC group were higher(P 0.05).There was no significant correlation between clinical stages and abnormal expression of Brn-3a and PPAR-γ(P 0.05),between microanatomic stages and abnormal expression of Brn-3a and PPAR-γ(P 0.05),and between the expression of Brn-3a and PPAR-γ(P 0.05).Conclusion Over expression of Brn-3a and PPAR-γcan be used as useful biomarkers to indicate CC and CIN.
【CateGory Index】: R737.33
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 LIANG Shaoqiang1 TU Qingsong2 HUANG Rong1 JIANG Jun1 JIANG Wuzhong1 YUAN Jun2 ZENG Xiaohong1 HE Han1 ZHOU Feifei1 1.Department of Radiotherapy,Tumor Hosipital of the First People's Hospital of Foshan,Foshan 528000 China;2.Department of Radiation Oncology,Xiangya Hospital of Central South University,Changsha 410008,China;The expression and significance of PPAR γ in cervical cancer[J];China Medicine and Pharmacy;2012-15
2 GUO Xiao-dong1,NIU Ke2,ZHAO Jing-min1,XIONG Lu1,ZHANG Xin1,ZHAO Yu-lai11Department of Pathology 302 Hospital of PLA,Beijing 100039;2Department of Obstetrics and Gynecology,First Affiliated Hospital of PLA General Hospital,Beijing 100048,China;Evaluation of Brn-3a immunocytochemistry of liquid-based ThinPrep cytology test in early diagnosis of cervical process[J];Chinese Journal of Cellular and Molecular Immunology;2011-07
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Axiangu· Hasimu,Lalai· Suzuke,LI Qiao-zhi(Department of Pathology,Xinjiang Medical University,Urumqi 830054,China);Expression and significance of PPARγin cervical intraepithelial neoplasia and in cervical carcinoma[J];Journal of Xinjiang Medical University;2007-06
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 LU E-mei,YE Jin-jun,HUANG Jian,WANG Hai-rong.Department of Radiotherapy,Jiangsu Cancer Hospital,Nanjing 210009,China;Expressions and clinical significances of PPARγ and p27 in cervical carcinoma[J];Chinese Clinical Oncology;2011-05
2 LI Sinan,CHEN Zhongdong(Department of Gynecology and Obstetrics,First Affiliated Hospital,Nanhua University,Hengyang Hunan 421001,China);Research advance of PPARγ in gynecologic oncology[J];International Journal of Pathology and Clinical Medicine;2009-03
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 LU E-mei,YE Jin-jun,HUANG Jian,WANG Hai-rong.Department of Radiotherapy,Jiangsu Cancer Hospital,Nanjing 210009,China;Expressions and clinical significances of PPARγ and p27 in cervical carcinoma[J];Chinese Clinical Oncology;2011-05
2 GUAN Yong-hong,ZOU Ying-gang,YU Xiao-yan.(The Second Clinical Hospital,Jilin University,Changchun 130041,China);The expression and significance of peroxisome proliferator-activated receptorγ(PPAR-γ) in cancer of cervix[J];Chinese Journal of Laboratory Diagnosis;2010-08
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 XIA Xue-wei~(1),SU Chang-bao~(1),XU Zhi-qin~(1),YIN Jian~(1),KONG Yan-guo~(1),MA Yan~(1),LIU Wei~(2) (1.Dept.Neurosurgery,Peking Union Medical College Hospital, Beijing 100730;2.Dept.Surgery,Liaohe Oilfield Central Hospital,Panjin 124000,China);Distribution and expression of peroxisome proliferator activated receptor γ in pituitary ACTH-secreting adenomas[J];Basic & Clinical Medicine;2006-03
2 WANG Xingpeng,XU Xuanfu,WANG Bingxian,et al.Department of Gastroenterology,Shanghai First People's Hospital,Shanghai 200080,China;Peroxisome proliferator activated receptor γ (PPARγ) is aberrantly expressed in pancreatic carcinoma[J];Chinese Journal of Experimental Surgery;2002-06
3 ZHANG Min,ZOU Ping,BAI Ming,TAO Xiao-nan,JIN Yang,GUO Rong. Department of Hematology, Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Apoptosis of human lung cancer cells induced by activated peroxisome proliferator-activated receptor-γ and its mechanism[J];National Medical Journal of China;2003-13
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved