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《Journal of Kunming Medical University》 2010-02
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The Effects of Gypenosides(GP) on Protein Expression of IκB and IKK in the Signaling Pathway of Nuclear Factor Kappa B in Photo-damaged Skin of Balb/C Mice

DENG Dan-qi1),WANG Yi-lin1),YUAN Li-mei1),HU Rong1),LIU Liu2)(1) Dept.of Dermatology & Rheumatology,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101;2) Dept.of Head and Neck Surgery,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China  
Objective To observe the effects of gypenosides(GP) on photo-damaged skin of mice and to explore the possible mechanisms.Methods We established Blab/C mouse skin photo-damage model by 7 times of UVB intermissive irradiation(every other day).The concentration of protein was detected with Brad-Ford,then the nuclear NF-κB Inhibitor(IκB) protein as well as IκB kinase(IKK) expression were detected by western blot.Results(1) In UVB irradiation group,the expression of IκB was significantly decreased compared to other groups,while IKK protein expression was higher than other groups;(2) In 1.5% gypenosides group and 6% gypenosides group the protein expression of IκB was significantly higher than that of UVB irradiation group,whereas IKK protein expression was significantly lower than that of UVB irradiation group,similar with the positive control group of vitamin E;(3) In pre-treated vitamin E group and 1.5% gypenosides group,IκB protein expression was higher than that of treatment with vitamin E and 1.5% gypenosides after UVB exposure ;(4) In pre-treated VitE group and 1.5% gypenosides group,IKK protein expression was lower than that of treatment with vitamin E and 1.5% gypenosides after UVB exposure.Conclusions UVB can significantly inhibit IκB protein and increase IKK protein expression in the Balb/C mouse skin tissue,thus activate of NF-κB(NF-kappa B).1.5% gypenosides and 6% gypenosides cream can enhance IκB protein expression in the Balb/C mouse skin tissue damaged by UVB exposure,reactivate IκB,and inhibit IKK protein activity,thereby inhibit the activity of NF-κB
【CateGory Index】: R285.5
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