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Therapeutic Study of Folium Ginkgo Pharmaceutics on Cerebral Ischemia

Fang Siwei Li Ninxian Wang Zican Wang Qiongxian (Department of Pathophysiology, Kunming Medical College, Kunming 650031)  
Applied were the models of transient cerebral ischemia in gerbils and of regional cerebral ischemia in rats, which were administered 30 minutes before ischemia with 20 mg/kg of folium ginkgo pharmaceutics (FGP) to observe its effect on ischemic brain injury. The results were demonstrated as follows: (1) in models of gerbils, which were given 4 day perfusion 10 min after the ligation of their bilateral arteries carotid, FGP obviously increased the survival neuron number of hippocampal CA1 area (133 13±20 99/mm, P0 01) as compared with that of control group (38 50±16 31/mm), the results being similar (P0 05) to those of Aniline group (165 42±29 63/mm) and Nimodipine group (182 00±67 00/mm); 2) 48 hours after the arterial occlusion on the left side of rat brain, FGP could evidently decrease (a) the infarcted area (respectively 42 84±10 61% and 23 06±6 15%, P0 05), (b) the water content at the central and peripheral areas of infarction, with (81 83±1 13)%, (81 18±1 44)% for the control group and (81 83±1 13)%, (79 69±0 52)% for FGP group (P0 05); (c) the sodium content at the central and peripheral areas of infarction, with (478 59±85 65) μmol/g, (415 65±154 93) μmol/g for the control group and (352 40±63 62) μmol/g, (243 65±56 15) μmol/g for FGP group (P0 05); and the calcium content at the central area of infarction, with (515 99±140 27) μg/g for the control group and (364 41±122 81) μg/g for FGP group (P0 05). All this suggested that FGP could alleviate ischemic brain injury, lessen infarction area and palliate encephaledema.
【Fund】: 国家自然科学基金
【CateGory Index】: R363
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