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《ACADEMIC JOURNAL OF KUNMING MEDICAL COLLEGE》 1999-01
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Effect of LBP 2 on Functions of Rats Peritoneal Macrophages in Vitro

Wang Ling 1) Zhao Chong 2) Qian Yukun 2) ( 1) Department of Microbiology and Immunology, Kunming Medical College, Kunming 650031; 2) Immunologic Research Center of Beijing Medical University, Beijing 100083)  
This research explored the effect of LBP 2 (Lycium Barbarum Polysaccharide 2) on functions of SD rats peritoneal macrophages (MΦ) and the possible immunomodulatory mechanism of LBP 2. Neutral red phagocytized by MΦ represented phagocytic activity. LBP 2 enhanced the activity of rats peritoneal macrophages to phagocytize neutral red in vitro with dose increased (0.32~20 mg/L). Moreover, the standard of cytokines was examined by the methods of biological activity. LBP 2 was shown to significantly induced intracellular and extracellular production of interleukin-1 (IL-1) and tumornecrosis factor (TNF) with LPS (10 mg/L) in 18~24 hours. LBP 2 increased the synthesis and release of IL-1, TNF from rats peritoneal MΦ in vitro. Therefore, the effect of LBP 2 on the production of IL-1, TNF from MΦ might be the main immunomodulatory mechanism of LBP 2 .
【CateGory Index】: R285.5
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