Effect of Epimedium on Bone Metabolism in Osteoporotic Rats

LI Hua-zhu,HUANG Wen-xiu,DU Zhi-bin,CHEN Jiang (Department of Implantology,Hospital of Stomatology,Fujian Medical University, Fuzhou 350002,Fujian Province,China)  

Objective:To study the influence of Epimedium on bone metabolism in osteoporotic rats.Methods:54 female SD Rats(3～4-month-old) were divided into three groups by randomized block design,which were Sham-operated groups(SHAM),ovariectomized group(OVX) and Epimedium with ovariectomized rats group(EP).When the osteoporotic model was established at 8~(th) weeks,daily oral administration of EP[5.36 g/(kg·d)]started in EP group,and rats in Sham and OVX groups were given vehicle accordingly.The rats were killed at 12~(th) week and 20~(th) week respectively,the serum was taken to analyze the biochemical markers of rats.Results:The weight of OVX group and EP group rats increased faster.At 20~(th) week,the level of P was significantly decreased in the OVX group compared with the SHAM group.The level of BALP was significantly increased in the EP group compared with two other groups at 12~(th) week.At 20~(th) week,the level of BGP in the EP group was significantly increased too.The levels of B-ALP were significantly decreased at 20~(th) week compared with 12~(th) week in all groups.Conclusion:Osteoporotic model was established at 8~(th) week by ovariectomizing rats.The results support a general beneficial effect of Epimedium on bone metabolism in osteoporotie rats.

【Key Words】： osteoporosis epimedium bone histomor-phometry
【Fund】： 国家卫生部科研课题基金(WKJ2008-2-064);; 福建省科技厅重点科研项目(2008Y0042)
【CateGory Index】： R285.5

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