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《Stomatology》 2006-06
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Expression and significance of hypoxia inducible factor-1α in osseous sarcoma of jaws

FENG Hong-jie,CHEN Wei-liang,LI Jin-song,PAN Chao-bin.(Department of Oral Maxillofacial Surgery,Hangzhou First People's Hospital,Hangzhou 310006,China)  
Objective To detect expression of HIF-1α in osseous sarcoma of jaws and study the relationship between HIF-1α and tumor angiogenesis,and clinicopathological characters.Method SP immunohistochemistry staining method was applied to detect the expression of HIF-1α and CD34 in osseous sarcoma of jaws,fibrous dysplasia of jaws and normal bone tissue.Results There is overexpression of HIF-1α in osseous sarcoma of jaws.Expression of HIF-1α correlates with microvessel density,size,pathological grade,and clinical classification of osseous sarcoma of jaws positively,but it doesn't correlate with metastasis of osseous sarcoma of jaws.Conclusion HIF-1α could promote tumor angiogenesis in osseous sarcoma of jaws,and HIF-1α may become the molecular target in anti-tumor therapy.
【Fund】: 广东省科技三项经费资助项目(2005A30801007)
【CateGory Index】: R739.8
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