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《Stomatology》 2006-06
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Expression and significance of hypoxia inducible factor-1α in osseous sarcoma of jaws

FENG Hong-jie,CHEN Wei-liang,LI Jin-song,PAN Chao-bin.(Department of Oral Maxillofacial Surgery,Hangzhou First People's Hospital,Hangzhou 310006,China)  
Objective To detect expression of HIF-1α in osseous sarcoma of jaws and study the relationship between HIF-1α and tumor angiogenesis,and clinicopathological characters.Method SP immunohistochemistry staining method was applied to detect the expression of HIF-1α and CD34 in osseous sarcoma of jaws,fibrous dysplasia of jaws and normal bone tissue.Results There is overexpression of HIF-1α in osseous sarcoma of jaws.Expression of HIF-1α correlates with microvessel density,size,pathological grade,and clinical classification of osseous sarcoma of jaws positively,but it doesn't correlate with metastasis of osseous sarcoma of jaws.Conclusion HIF-1α could promote tumor angiogenesis in osseous sarcoma of jaws,and HIF-1α may become the molecular target in anti-tumor therapy.
【Fund】: 广东省科技三项经费资助项目(2005A30801007)
【CateGory Index】: R739.8
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【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 ZHENG Jin-hua, WANG Qi, LI Hui-ping, TENG he, XIE Li-ping, LIU Shi-long. Department of Anatomy, Harbin Medical University, Harbin 150081 China;Comparative study on the tongue carcinoma model induced by local application both of 7,12-dimethylbenz [a] anthracene (DMBA) and injury[J];Anatomy Research;2007-06
2 LI Jun. Department of Stomatology,the first hospital of Xingning, Xingning 514500,China;Clinical analysis of 31 patients with facial sebaceous cyst resected by intraoral incision[J];International Medicine & Health Guidance News;2009-07
3 ZHANG Mei1,XU Zhong-fa1,TAO Yang1,PAN Yi2,YU Yang3,ZHAO Wen-chuan3.(1. Dept. of Head and Neck Surgery,Academy of Medical Science,The Affiliated Hospital of Shandong,Jinan 250031,China; 2. Dept. of Pathology,The Affiliated Cancer Hospital,Tianjin Medical University,Tianjin 300060,China; 3. Dept. of Head and Neck Surgery,The Affiliated Cancer Hos-pital,Tianjin Medical University,Tianjin 300060,China);Clinical analysis of 25 patients with glossal adenoid cystic carcinoma[J];International Journal of Stomatology;2009-02
4 LIU Hua1, YU Hua-fang2, ZHAO Hong-wei3. (1. Dept. of Biochemistry and Molecular Biology, Guiyang Medical College, Guiyang 550002, China; 2. Dept. of Oral and Maxillofacial Surgery, The Affiliated Hospital of Guiyang Medical College, Guiyang 550002, China; 3. Key. Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China);Study on the relationship between function of blood and tumor recurrence in oral squamous cell carcinomas[J];West China Journal of Stomatology;2007-05
5 ZHANG Ming-bin1,2,CHEN Wan-tao1,ZHANG Chen-ping1,ZHU Han-guang, SUN Jian,YE Wei-min,WANG Li-zhen,HU Yu-hua(1.Department of Oral and Maxillofacial Surgery,Shanghai Key Laboratory of Stomatology School of Stomatology,Shanghai Ninth People's Hospital,School of Medicine, Shanghai Jiaotong University,Shanghai 200011;2.Department of Stomatology, Central Hospital of Tai'an,Tai'an 271000,Shandong Province,China);Bax,Bcl-2 and Survivin Expression in Oral Squamous Cell Carcinoma: Significance to Prognosis[J];Journal of Oral and Maxillofacial Surgery;2006-04
6 WANG De-ming WU Yan-chang WANG Wei LI Fang Department of Oral and Maxillofacial Surgery ZHAO Er-yang Department of Oral Pathology,School and Hospital of Stomatology,Harbin Medical University,Harbin 150001,Heilongjiang Province,China;Expression of Fascin and its Significance in Oral Squamous Cell Carcinoma[J];Journal of Oral and Maxillofacial Surgery;2008-01
7 YU Yang,QIU Wei-liu,Lü Yan,YE Dong-xia,GUO Wei(Department of Oral and Maxillofacial Surgery,Shanghai Ninth People's Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai Research Institute of Stomatology,Shanghai Key Laboratory of Stomatology,Shanghai 200011,China);Nude Mice Metastasis Model of Human Oral Squamous Carcinoma Constructed Using Tca8113 Cell[J];Journal of Oral and Maxillofacial Surgery;2009-03
8 FENG Hong-jie,CHENG Wei-liang,LI Jin-song,LI Hai-gan,PAN Chao-bin.Department of Oral-Maxillofacial Surgery,Hangzhou FirstPeople's Hospital,Hangzhou 310006,China;Expression and significance of inducible nitric oxide synthase in osseous sarcoma of jaws[J];Journal of Clinical Stomatology;2006-04
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 HAO Lang-song,WANG Geng,QIAN Kun,LUO Ting,LI Xiao-jun,WU Xiao-ting~△.Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;HIF-1α Expression and Relationship Involving Tumor Cell Proliferation and Angiogenesis in Human Breast Carcinoma[J];Journal of Sichuan University(Medical Science Edition);2007-01
2 LI Fan1 YANG Weimin1 YE Zhangqun1(1Department of Urology,TongJi Hospital,TongJi Medical College,HuaZhong University of Science and Technology,Wuhan,430030,China);HIF-1α expression correlates with angiogenesis in bladder cancer[J];Journal of Clinical Urology;2007-04
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